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| 棉酚对雄性布氏田鼠的不育作用 | |
| 引用本文： | 李根,郭永旺,吴新平,海淑珍.棉酚对雄性布氏田鼠的不育作用[J].中国媒介生物学及控制杂志,2009,20(5):404-406. |
| 作者姓名： | 李根 郭永旺 吴新平 海淑珍 |
| 作者单位： | 1. 中国农业大学农学与生物技术学院植物检疫与农业生态健康系,北京,100193 2. 全国农业技术推广服务中心 3. 农业部药品检定所 |
| 基金项目： | 农业部专项资助项目，"十一五"科技支撑项目，国家重点基础研究发展计划"973"资助项目 |
| 摘 要： | 目的测定室内条件下棉酚对布氏田鼠的不育效果。方法采用一次性定量灌胃法测定该药对试鼠精子品质及睾丸、附睾组织的作用。结果棉酚可对精子细胞和精母细胞造成损害，并损伤睾丸组织。剂量在20～100mg／kg时，睾丸和附睾脏器系数明显下降；高于20ms／ks的剂量导致精子密度下降、精子畸形率明显增加；剂量高于60mg／kg对布氏田鼠有致死作用。结论20～100mg，kg剂量的棉酚对雄性布氏田鼠有明显的抗生育效果，且高剂量的棉酚对布氏田鼠有致死作用。 |
| 关 键 词： | 雄性不育剂 布氏田鼠 棉酚 |
A study on anti-fertility of gossypol to Lasiopodomys brandtii |
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| Institution: | LI Gen, GUO Yong-wang, WU Xin-ping, HAI Shu-zhen(China Agricultural University, Beijing 100193, China) |
| Abstract: | Objective To study the anti-fertility effect of gossypol to Lasiopodomys brandtii. Methods The effect of gossypol to sperm quality, testis and epididymis tissues of Lbrandtii was tested with one-off quantitative gastric gavages. Results Gossypol did harm to spermatids, spermatocytes and testis tissue lesions. Testis and epididymis tissues coefficient decreased obviously at the dosage of 20-100 mg/kg, and sperm concentration reduced and sperm malformation increased at 20 mg/kg. It leaded to the death of Lbrandtii when the dosage exceeded 60 mg/kg. Conclusion The gossypol had significant anti-fertility effect on male L.brandtii at the concentration of 20-100 mg/kg, but it was lethal at high eoncentrtion. |
| Keywords: | Male sterility Lasiopodomys brandtii Gossypol |
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