慢性阻塞性肺病患者新喋呤浓度及与病情严重程度的关系

目的:探讨新喋呤浓度与慢性阻塞性肺病(chronic obstruction pulmonary disease,COPD)患者病情严重程度的关系。方法:纳入华中科技大学同济医学院附属武汉中心医院COPD患者65例为COPD组,25名健康者为对照组,ELISA检测COPD组与对照组血清和痰液中新碟呤浓度,分析其和COPD严重程度的关系。结果:COPD组血清中新喋呤浓度高于对照组[(20.34±4.70)nmol/L vs(6.27±3.35)nmol/L,t=5.556,P=0.015];COPD组痰液中新喋呤浓度高于对照组[(32.07±8.14)nmol/L vs(4.13±2.25)nmol/L,t=7.483,P=0.005];COPD稳定期患者血清中新喋呤浓度低于COPD急性恶化期患者[(14.69±4.76)nmol/L vs(23.47±2.56)nmol/L,t=3.005,P=0.042];COPD稳定期患者痰液中新喋呤浓度低于COPD急性恶化期患者[(27.91±5.95)nmol/L vs(39.94±5.47)nmol/L,t=4.723,P=0.020]。COPD极重度患者血清和痰液新喋呤浓度高于轻、中、重度患者,血清和痰液新喋呤浓度间呈正相关(r=0.679,P<0.001)。目前吸烟者血清新碟呤浓度高于过去吸烟者和非吸烟者(F=4.972,P=0.037),目前吸烟者痰液新碟呤浓度高于过去吸烟者和非吸烟者(F=5.830,P=0.021)。结论:COPD患者血清与痰液中新蝶呤浓度与患者病情严重程度相关,且与患者吸烟状况相关。

Relationship between neopterin concentration and severity of chronic obstructive pulmonary disease

Objective:To investigate the association between the concentration of neopterin and the severity of chronic obstruction pulmonary disease(COPD).Methods:Sixty-five COPD patients in our hospital was enroll as a COPD group,while 25 healthy people as a control group.The concentration of neopterin in serum and sputum samples from the COPD group and the control group was detected by ELISA,and their association with the severity of COPD was also analyzed.Results:The concentration of serum neopterin in COPD group was significantly higher than that in control group [(20.34±4.70) nmol/L vs(6.27±3.35) nmol/L,t=5.556,P=0.015].Meanwhile,the concentration of sputum neopterin in the COPD group was also significantly higher than that in the control group [(32.07±8.14) nmol/L vs(4.13±2.25) nmol/L,t=7.483,P=0.005].The concentration of serum neopterin in stable COPD patients was significantly lower than that in patients with acute exacerbation of COPD [(14.69±4.76) nmol/L vs(23.47± 2.56) nmol/L,t=3.005,P=0.042].Also,the concentration of sputum neopterin in stable COPD patients was significantly lower than that in patients with acute exacerbation of COPD [(27.91±5.95) nmol/L vs(39.94± 5.47) nmol/L,t=4.723,P=0.020].The concentration of serum and sputum neopterin in extremely severe COPD patients was significantly higher than mild,moderate and severe COPD patients.There was a positive correlation between serum and sputum neopterin concentration(r=0.679,P<0.001).The concentration of current smoker serum neopterin was statistically higher that of past smokers and of non-smokers(F=4.972,P=0.037).Also,the concentration of current smoker sputum neopterin was statistically higher that of past smokers and of non-smokers(F=5.830,P=0.021).Conclusion:Concentrations of neopterin in COPD patients’ blood and sputum samples are related with COPD severity,which also relate with patients’ smoking status.