血清维生素D水平与女童特发性中枢性性早熟的相关性

目的:探讨血清维生素D的水平与女童特发性中枢性性早熟(idiopathic central precocious puberty,ICPP)的关系,为临床预防及治疗提供依据。方法:收集2017年2月至2018年8月在溧阳市中医医院门诊就诊的92例特发性中枢性性早熟的女童作为观察组,另85例健康体检女童作为对照组,记录2组的一般资料;检测血清游离T3(FT3)、血清游离T4(FT4)、促甲状腺素(TSH)、泌乳素(PRL)、黄体生成素(LH)及峰值、卵泡刺激素(FSH)及峰值、雌二醇(E2)及25-羟基维生素D(25-OHD)水平。结果:ICPP女童血清中维生素D含量明显低于对照组,两组比较差异有统计学意义(P<0.001);维生素D缺乏组ICPP女童的BA,BA/CA,MBISDS,子宫容积,卵巢体积及最大卵泡直径与维生素D正常组ICPP女童相比较无明显差异(P>0.05),但乳房发育年龄两组差异有统计学意义(P<0.05);维生素D缺乏组ICPP女童TSH,PRL,LH,FSH,LH峰值及FSH峰值与维生素D正常组ICPP女童相比较无明显差异(P>0.05),但E2水平两组差异有统计学意义(P<0.05)。结论:维生素D缺乏与特发性中枢性性早熟女童乳房发育年龄存在相关性,可能与E2水平有关。

Correlation between serum vitamin D level and idiopathic central precocious puberty in girls

Objectives:To investigate the correlation between serum vitamin D level and idiopathic central precocious puberty(ICPP) in girls,in order to provide basis for the clinical prophylaxis and treatment.Methods:The clinical data of 92 girls with ICPP as the observation group and 85 healthy girls as the control group in our hospital from February 2017 to August 2018 were recorded.Their serum FT3,FT4,TSH,PRL,LH,FSH,peak of LH,peak of FSH,E2 and 25-OHD levels were detected.Results:The serum vitamin D levels in girls with ICPP were obviously lower than those in healthy girls,which had statistically significant difference(P<0.001).BA,BA/CA,MBI SDS,uterine volume,ovarian volume and maximum follicular diameter had no significant difference between patients with vitamin D deficiency and those not in the observation group(P>0.05).However,breast development had significant difference between the 2 groups(P<0.05).In addition,difference in TSH,PRL,LH,FSH,LH surge and FSH peak were not significant between patients with vitamin D deficiency and those with normal vitamin D(P>0.05),but the serum E2 levels had significant difference between the two groups(P<0.05).Conclusion:Lack of serum vitamin D and breast development age in ICPP girls are closely related,which perhaps relates to the serum E2 levels.