钠钾镁钙葡萄糖注射液对剖宫产产后出血影响的荟萃分析

目的:系统评价钠钾镁钙葡萄糖注射液对剖宫产产后出血的影响。方法:检索中国知网、万方数据库、维普中文科技期刊数据库和PubMed,Web of Science,Embase数据库,纳入钠钾镁钙葡萄糖注射液用于剖宫产的随机对照试验,以术后2 h和术后24 h出血量为结局指标,对纳入的文献进行荟萃分析。结果:最终纳入4篇文献,均为中文4篇,共683例患者。荟萃分析结果显示:钠钾镁钙葡萄糖注射液组术后2 h出血量小于乳酸钠林格注射液组术后2 h出血量(WMD=-56.79,95%CI:-69.76^-43.82,P<0.001,中等级别证据);钠钾镁钙葡萄糖注射液组术后24h出血量小于乳酸钠林格注射液组术后24 h出血量(WMD=-119.75,95%CI:-141.10^-98.40,P<0.001,中等级别证据)。结论:钠钾镁钙葡萄糖注射液能有效预防剖宫产产后出血。

Effect of sodium potassium magnesium calcium and glucose injection on postpartum hemorrhage in cesarean section: A Meta-analysis

Objective:To systematically review the efficacy of sodium potassium magnesium calcium and glucose injection on postpartum hemorrhage in cesarean section.Methods:CNKI,Wanfang and VIP database,PubMed,Web of Science,Embase were searched.Randomized controlled trials(RCTs)which sodium,potassium,magnesium,calcium and glucose injection for after cesarean section were included.The clinical symptom remission rate and endoscopic cure rate were used as the outcome index.Meta-analysis was performed on the included literatures.Results:A total of 4 Chinese RCTs were included involving 683 patients.Results of Meta-analysis showed that:The blood loss 2 hours after operation in the sodium potassium magnesium calcium and glucose injection group was lower than that in the sodium lactate rlinger injection group,and the difference was statistically significant(WMD=−56.79,95%CI:−69.76 to−43.82,P<0.00001,medium level evidence).The blood loss 24 h after operation in the sodium potassium magnesium calcium glucose injection group was lower than that in the sodium lactate ringer injection group,and the difference was statistically significant(WMD=−119.75,95%CI:−141.10 to−98.40,P<0.00001,medium level evidence).Conclusion:Sodium potassium magnesium calcium glucose injection can effectively prevent postpartum hemorrhage in cesarean section.But multiple center studies are required to validate those conclusions.