内镜活检胃癌组织中MUC3A,MUC13表达及与病理参数和预后的关系

目的:探讨内镜活检胃癌组织中黏蛋白3A(MUC3A)、黏蛋白13(MUC13)表达及与病理参数和预后的关系。方法:选取2013年1月至2014年12月南阳市中心医院肿瘤科收治的接受内镜活检的116例患者胃癌组织和癌旁正常组织进行分析,采用免疫组织化学法检测所有组织样本中MUC3A,MUC13表达,观察二者表达情况,并分析二者与临床病理参数及预后的关系。结果:胃癌患者组织MUC3A,MUC13阳性率分别为68.97%和66.38%,高于正常组织的32.76%和7.76%(P<0.05);胃癌组织中MUC3A,MUC13表达与年龄、性别、肿瘤大小无关(P>0.05),与组织分化、浸润深度、TNM分期、淋巴结转移有关(P<0.05);随访5年结果显示:胃癌组织中MUC3A阳性患者中位生存时间为(40.50±1.95)个月,低于阴性患者的(48.67±2.51)个月(P<0.05),MUC3A阳性患者预后5年生存率为32.50%,低于阴性患者的55.56%(P<0.05);MUC13阳性患者中位生存时间为(38.52±1.92)个月,低于阴性患者的(49.06±2.71)个月(P<0.05),MUC13阳性患者预后5年生存率为30.00%,低于阴性患者的61.11%(P<0.05);COX多因素回归分析显示:TNM分期,淋巴结转移,MUC3A,MUC13是影响胃癌预后的独立危险因素(P<0.05)。结论:MUC3A,MUC13在胃癌组织中呈高表达,且与临床病理参数及预后密切相关,二者均有望作为判定胃癌发生发展及预后评估的参考指标。

Expressions of MUC3A and MUC13 in endoscopic biopsy of gastric cancer tissues and their relationships with pathological parameters and prognosis

Objective:To investigate the expressions of mucin 3 A(MUC3 A) and mucin 13(MUC13) in endoscopic biopsy of gastric cancer and their relationships with pathological parameters and prognosis.Methods:A total of 116 cases of gastric cancer tissues and adjacent normal tissues which underwent endoscopic biopsy in the Oncology Department of our hospital from January 2013 to December 2014 were selected,the expressions of MUC3 A and MUC13 in all tissue samples were detected by immunohistochemistry,the relationships between them with clinicopathological parameters and prognosis were analyzed.Results:The positive rates of MUC3 A and MUC13 in gastric cancer tissues were 68.97% and 66.38%,respectively,which were higher than those in normal tissues(32.76% and 7.76%,P<0.05);the expressions of MUC3 A and MUC13 in gastric cancer tissues were not related to age,sex and tumor size(P>0.05),but to tissue differentiation,depth of invasion,TNM stage and lymph node metastasis(P<0.05);the results of 5-year follow-up showed that the median survival time of MUC3 A positive patients in gastric cancer tissues was(40.50±1.95) months,which was lower than(48.67±2.51) months of negative patients(P<0.05),the 5-year survival rate of MUC3 A positive patients was 32.50%,which was lower than 55.56% of negative patients(P<0.05);the median survival time of MUC13 positive patients was(38.52±1.92) months,which was lower than(49.06±2.71) months of negative patients(P<0.05),the 5-year survival rate of MUC13 positive patients was 30.00%,which was lower than 61.11% of negative patients(P<0.05);COX multivariate regression analysis showed that TNM stage,lymph node metastasis,MUC3 A and MUC13 were independent risk factors affecting the prognosis of gastric cancer(P<0.05).Conclusion:MUC3 A and MUC13 are highly expressed in gastric cancer tissues,which are closely related to clinicopathological parameters and prognosis.Both of them are expected to be used as reference indicators for judging the occurrence,development and prognosis of gastric cancer.