善得定治疗癌性上消化道出血临床观察

目的为观察善得定治疗恶性肿瘤所致上消化道出血的疗效及副作用方法选用恶性肿瘤所致上消化道出血６６例，随机分为善得定治疗组和垂体后叶素对照组，治疗组病人先用善得定０１ｍｇ＋０．９％ＮＳ２０ｍｌ静推，后用善得定以每小时２５微克滴速静滴维持２４～４８小时，对照组用垂体后叶素以每小时２～５Ｕ滴速静滴维持２４～４８小时，同时给硝酸甘油０．５ｍｇ吞下含服。结果治疗组总有效率为８８２３％（３０／３４），对照组总有效率为６２５０％（２０／３２），两组差异有显著意义（Ｐ＜００５），治疗组每例平均输血量为７００８０±３２７１８ｍｌ，对照组输血量平均每例为１１７６００±３２４１２ｍｌ，两组差异显著（Ｐ＜０００１）。两组均无严重副作用。结论癌性上消化道出血是晚期肿瘤常见并发症及致死原因之一，善得定较传统的垂体后叶素治疗具有止血快、止血率高，副作用少等优点，且可减少输血量，值得临床广泛推广使用。

Clinical observation of Sandostatin in the treatment carcinomatous hemorrhage of upper digestive tract

Aim To observe the therapeutic effectiveness and reaction of Sandostatin in the treatment of hemorrhage of upper digestive tract caused by malignant tumor. Methods We choosed 66 cases with hemorrhage of upper digestive tract caused by malignant tumor.They were randomly allocated into the Sandostatin therapeutic group and the pitressin control group.The patients of the therapeutic group were first given Sandostatin 0.1 mg 0.9% N.S20ml IV,then 25Pg per hour by continuous intrevenous drip for 24-48 hours.In the control group,pitressin was given 2-5u pre hour by continuous drip for 24-48 hours.At the same time,the control group were given nitroglycerin 0.5mg Result Sublingually The effective rate o the therapeutic rate the therapeutic group was 88.23%(30/34).And it was 62.5%(30/32) in the control group.there was significant difference between the two groups(P<0.05).In the therapeutic group,the average amount of blood transfusion of each case was 700.80 /-327.18ml.And it was 1176.00 /-324.12 ml in the control grup .So the two groups had significant difference(P<0.001).Both the two groups had no serious side effectiveness. Conclusion Carcinomatous hemorrhage of upper digestive tract was one of the common complications and lethal causes in the late stage cancer.Sandosatin had dominance of high speed hemostasis,high hemostatic rate and low side effectiveness.And it can decrease the amount of blood transfusion.So it should be a widely clinical use.