| 食道通结颗粒联合化疗治疗中晚期食管癌的近期疗效观察 |
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| 引用本文： | 蔡霄月,杨茜文,卢文峰,金长娟,张铭,崔清,李蕾,郭毅峻,董昀,周亚宁. 食道通结颗粒联合化疗治疗中晚期食管癌的近期疗效观察[J]. 上海中医药杂志, 2017, 51(7): 44-47 |
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| 作者姓名： | 蔡霄月 杨茜文 卢文峰 金长娟 张铭 崔清 李蕾 郭毅峻 董昀 周亚宁 |
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| 作者单位： | 上海交通大学附属胸科医院中西医结合科,上海,200030,上海交通大学医学院研究生院,上海,200025,上海交通大学医学院研究生院,上海,200025,上海交通大学附属胸科医院中西医结合科,上海,200030,上海交通大学附属胸科医院中西医结合科,上海,200030,上海交通大学附属胸科医院中西医结合科,上海,200030,上海交通大学附属胸科医院中西医结合科,上海,200030,上海交通大学附属胸科医院中西医结合科,上海,200030,上海交通大学附属胸科医院中西医结合科,上海,200030,上海交通大学附属胸科医院中西医结合科,上海,200030 |
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| 基金项目： | 上海市科委科研计划项目(16401933400)；上海市卫计委进一步加快中医药事业发展三年行动计划资助项目(ZY-CCC-3045)；上海市卫计委中医药科研专项2016-2017年度课题(2016JP004) |
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| 摘 要： | 目的观察食道通结颗粒联合化疗治疗中晚期食管癌的近期临床疗效。方法将80例中晚期食管癌患者随机分为治疗组和对照组,每组40例。对照组予紫杉醇加卡铂的方案化疗,治疗组在对照组治疗措施基础上加用食道通结颗粒。两组疗程均为2个月,观察近期疗效,比较中医证候积分、化疗不良反应及免疫功能指标的变化情况。结果 (1)治疗组、对照组临床总有效率分别为55.00%、32.50%;组间近期疗效比较,治疗组明显优于对照组(P0.05)。(2)组间治疗后中医证候积分比较,差异有统计学意义,治疗组中医证候积分明显低于对照组(P0.05)。(3)试验期间,组间化疗不良反应(白细胞、血小板减少,贫血,恶心呕吐)比较,治疗组反应程度明显低于对照组(P0.05)。(4)组间治疗后比较,CD3~+、CD4~+、CD8~+、CD4~+/CD8~+及NK细胞水平差异有统计学意义(P0.05)。结论食道通结颗粒可显著提高中晚期食管癌的近期疗效,改善临床症状,减轻化疗后不良反应,同时调节患者的免疫功能。
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| 关 键 词： | 食管癌 中晚期 食道通结颗粒 化疗 中西医结合 减毒增效 |
| 收稿时间： | 2017-01-16 |
Short term efficacy observation of Shidao Tongjie Granule combined with chemotherapy in the treatment of advanced esophageal cancer |
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| CAI Xiao-yue,YANG Xi-wen,LU Wen-feng,JIN Chang-juan,ZHANG Ming,CUI Qing,LI Lei,GUO Yi-jun,DONG Yun and ZHOU Ya-ning. Short term efficacy observation of Shidao Tongjie Granule combined with chemotherapy in the treatment of advanced esophageal cancer[J]. Shanghai Journal of Traditional Chinese Medicine, 2017, 51(7): 44-47 |
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| Authors: | CAI Xiao-yue YANG Xi-wen LU Wen-feng JIN Chang-juan ZHANG Ming CUI Qing LI Lei GUO Yi-jun DONG Yun ZHOU Ya-ning |
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| Affiliation: | Department of Integrated Chinese and Western Medicine,Shanghai Chest Hospital Affiliated to Shanghai Jiao Tong University,Shanghai,200030,Graduate School,Medical College of Shanghai Jiao Tong University,Shanghai,200025,Graduate School,Medical College of Shanghai Jiao Tong University,Shanghai,200025,Department of Integrated Chinese and Western Medicine,Shanghai Chest Hospital Affiliated to Shanghai Jiao Tong University,Shanghai,200030,Department of Integrated Chinese and Western Medicine,Shanghai Chest Hospital Affiliated to Shanghai Jiao Tong University,Shanghai,200030,Department of Integrated Chinese and Western Medicine,Shanghai Chest Hospital Affiliated to Shanghai Jiao Tong University,Shanghai,200030,Department of Integrated Chinese and Western Medicine,Shanghai Chest Hospital Affiliated to Shanghai Jiao Tong University,Shanghai,200030,Department of Integrated Chinese and Western Medicine,Shanghai Chest Hospital Affiliated to Shanghai Jiao Tong University,Shanghai,200030,Department of Integrated Chinese and Western Medicine,Shanghai Chest Hospital Affiliated to Shanghai Jiao Tong University,Shanghai,200030 and Department of Integrated Chinese and Western Medicine,Shanghai Chest Hospital Affiliated to Shanghai Jiao Tong University,Shanghai,200030 |
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