| 中药单体逆转MDR1介导的肿瘤多药耐药机制研究进展 |
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| 引用本文： | 袁玉霞,殷佩浩. 中药单体逆转MDR1介导的肿瘤多药耐药机制研究进展[J]. 上海中医药杂志, 2017, 51(3): 96-98 |
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| 作者姓名： | 袁玉霞 殷佩浩 |
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| 作者单位： | 上海中医药大学附属普陀医院普外科,上海,200062,上海中医药大学附属普陀医院普外科,上海,200062 |
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| 基金项目： | 国家自然科学基金面上项目(81473482) |
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| 摘 要： | 综述中药单体逆转多药耐药基因1(MDR1)介导的肿瘤多药耐药机制研究进展。中药单体主要通过抑制MDR1基因的表达、抑制P-gp活性、抑制ATP酶、逆转凋亡抵制、抑制蛋白激酶活性等途径逆转MDR1介导的肿瘤多药耐药。
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| 关 键 词： | 肿瘤 多药耐药 MDR1 中药单体 逆转 |
| 收稿时间： | 2016-05-16 |
Mechanism research of Chinese herbal monomers on reversing MDR1-induced tumor multidrug resistance |
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| YUAN Yu-xia and YIN Pei-hao. Mechanism research of Chinese herbal monomers on reversing MDR1-induced tumor multidrug resistance[J]. Shanghai Journal of Traditional Chinese Medicine, 2017, 51(3): 96-98 |
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| Authors: | YUAN Yu-xia and YIN Pei-hao |
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| Affiliation: | Department of General Surgery,Putuo Hospital Affiliated to Shanghai University of Traditional Chinese Medicine,Shanghai,200062 and Department of General Surgery,Putuo Hospital Affiliated to Shanghai University of Traditional Chinese Medicine,Shanghai,200062 |
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| Abstract: | This paper reviewed the mechanism of Chinese herbal monomers on reversing multidrug resistance gene 1 (MDR1) -induced tumor multidrug resistance. The mechanisms mainly include inhibiting the gene expression of MDR1, inhibiting the activity of P-gp, inhibiting ATP enzyme, reversing apoptosis, inhibit the activity of protein kinase and so on. |
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