| 祛瘀生新方联合美沙拉秦治疗轻中度溃疡性结肠炎的临床研究 |
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| 引用本文： | 干丹,韩昌鹏,冯卓,金炜,杨豪杰,李盈,崔灿,梁榕钰,王云云,王振宜.祛瘀生新方联合美沙拉秦治疗轻中度溃疡性结肠炎的临床研究[J].上海中医药杂志,2017,51(8):54-57. |
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| 作者姓名： | 干丹 韩昌鹏 冯卓 金炜 杨豪杰 李盈 崔灿 梁榕钰 王云云 王振宜 |
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| 作者单位： | 上海中医药大学附属岳阳中西医结合医院肛肠科,上海,200437,上海中医药大学附属岳阳中西医结合医院肛肠科,上海,200437,上海中医药大学附属岳阳中西医结合医院肛肠科,上海,200437,上海中医药大学附属岳阳中西医结合医院肛肠科,上海,200437,上海中医药大学附属岳阳中西医结合医院肛肠科,上海,200437,上海中医药大学附属岳阳中西医结合医院肛肠科,上海,200437,上海中医药大学附属岳阳中西医结合医院肛肠科,上海,200437,上海中医药大学附属岳阳中西医结合医院肛肠科,上海,200437,上海中医药大学附属岳阳中西医结合医院肛肠科,上海,200437,上海中医药大学附属岳阳中西医结合医院肛肠科,上海,200437 |
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| 基金项目： | 国家自然科学基金(青年)项目(81403399；81603633)；上海市科委科研计划项目(16401971400)；上海市卫计委第三批中医临床优势专科基金资助项目(ZYSXD-YL-YSZK008)；上海市卫生局杏林新星计划项目(ZY3-RCPY-2-2014) |
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| 摘 要： | 目的观察祛瘀生新方联合美沙拉秦治疗轻中度溃疡性结肠炎(UC)的临床疗效。方法将72例轻中度溃疡性结肠炎患者随机分为治疗组与对照组,每组36例。治疗组予祛瘀生新方联合美沙拉秦治疗,对照组仅予美沙拉秦治疗。两组疗程均为1个月,观察临床疗效,比较改良Mayo评分、UC生活质量评分及相关生化指标C反应蛋白(CRP)、红细胞沉降率(ESR)的变化情况。结果①试验期间,治疗组脱落1例(因失访),最终完成试验者对照组36例、治疗组35例。②治疗组、对照组临床总有效率分别为88.57%、75.00%;组间临床疗效比较,治疗组明显优于对照组(P0.05)。③治疗前后组内比较,两组改良Mayo评分差异均有统计学意义,均明显下降(P0.05)。组间治疗前后差值比较,治疗组评分改变明显多于对照组(P0.05)。④组间治疗后比较,UC生活质量评分(肠道症状、全身症状)差异有统计学意义,治疗组明显高于对照组(P0.05)。⑤组间治疗后比较,CRP、ESR水平差异有统计学意义,治疗组明显低于对照组(P0.05)。结论祛瘀生新方联合美沙拉秦治疗轻中度溃疡性结肠炎,可明显改善活动期临床症状,抑制体内炎症反应,提高患者生活质量。
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| 关 键 词： | 溃疡性结肠炎 美沙拉秦 祛瘀生新方 补虚祛瘀生肌 |
| 收稿时间： | 2017/3/18 0:00:00 |
Clinical research of Quyu Shengxin Formula combined with mesalazine in treating mild to moderate ulcerative colitis |
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| GAN Dan,HAN Chang-peng,FENG Zhuo,JIN Wei,YANG Hao-jie,LI Ying,CUI Can,LIANG Rong-yu,WANG Yun-yun and WANG Zhen-yi.Clinical research of Quyu Shengxin Formula combined with mesalazine in treating mild to moderate ulcerative colitis[J].Shanghai Journal of Traditional Chinese Medicine,2017,51(8):54-57. |
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| Authors: | GAN Dan HAN Chang-peng FENG Zhuo JIN Wei YANG Hao-jie LI Ying CUI Can LIANG Rong-yu WANG Yun-yun and WANG Zhen-yi |
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| Institution: | Department of Coloproctology, Yueyang Hospital of Integrated Traditional Chinese and Western Medicine, Shanghai University of Traditional Chinese Medicine, Shanghai, 200437,Department of Coloproctology, Yueyang Hospital of Integrated Traditional Chinese and Western Medicine, Shanghai University of Traditional Chinese Medicine, Shanghai, 200437,Department of Coloproctology, Yueyang Hospital of Integrated Traditional Chinese and Western Medicine, Shanghai University of Traditional Chinese Medicine, Shanghai, 200437,Department of Coloproctology, Yueyang Hospital of Integrated Traditional Chinese and Western Medicine, Shanghai University of Traditional Chinese Medicine, Shanghai, 200437,Department of Coloproctology, Yueyang Hospital of Integrated Traditional Chinese and Western Medicine, Shanghai University of Traditional Chinese Medicine, Shanghai, 200437,Department of Coloproctology, Yueyang Hospital of Integrated Traditional Chinese and Western Medicine, Shanghai University of Traditional Chinese Medicine, Shanghai, 200437,Department of Coloproctology, Yueyang Hospital of Integrated Traditional Chinese and Western Medicine, Shanghai University of Traditional Chinese Medicine, Shanghai, 200437,Department of Coloproctology, Yueyang Hospital of Integrated Traditional Chinese and Western Medicine, Shanghai University of Traditional Chinese Medicine, Shanghai, 200437,Department of Coloproctology, Yueyang Hospital of Integrated Traditional Chinese and Western Medicine, Shanghai University of Traditional Chinese Medicine, Shanghai, 200437 and Department of Coloproctology, Yueyang Hospital of Integrated Traditional Chinese and Western Medicine, Shanghai University of Traditional Chinese Medicine, Shanghai, 200437 |
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