2,4-dinitro-5-ethyleneiminobenzamide (CB 1954): a potent and selective inhibitor of the growth of the Walker carcinoma 256 |
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| Authors: | L M Cobb T A Connors L A Elson A H Khan B C Mitchley W C Ross M E Whisson |
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| Affiliation: | 1. State Key Laboratory for Conservation and Utilization of Subtropical Agro-Bioresources, Animal Reproduction Institute, Guangxi University, Nanning 530004, Guangxi, PR China;2. State Key Laboratory for Conservation and Utilization of Subtropical Agro-Bioresources, College of Life Science and Technology, Guangxi University, Nanning 530004, Guangxi, PR China;3. Reproductive Center, General Hospital of People''s Liberation Army Air Force, Beijing 100142, PR China;1. Department of General Thoracic Surgery, Teikyo University School of Medicine, Itabashi-ku, Tokyo, Japan;2. Department of Radiology, Teikyo University School of Medicine, Itabashi-ku, Tokyo, Japan;1. Jet Propulsion Laboratory, California Institute of Technology, Pasadena, CA, USA;2. NOAA/NESDIS/STAR, College Park, MD, USA;3. NASA Goddard Space Flight Center, Greenbelt, MD, USA;4. Earth System Science Interdisciplinary Center, University of Maryland, College Park, MD, USA;5. Department of Geography and Earth Sciences, Aberystwyth University, Aberystwyth, UK;6. Centre of Atmospheric and Ocean Studies, University of Allahabad, Allahabad, India;1. School of Materials Science and Engineering, The Key Laboratory of Material Processing and Mold of Ministry of Education, Zhengzhou University, Zhengzhou, Henan 450001, PR China;2. Integrated Composites Laboratory (ICL), Department of Chemical & Biomolecular Engineering, University of Tennessee, Knoxville, TN 37996, USA |
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| Abstract: | The carcinostatic and pharmacological properties of a new cytotoxic agent, 2,4-dinitro-5-ethyleneiminobenzamide (CB 1954) have been investigated. CB 1954 exhibits a highly specific inhibitory effect on the growth of the Walker rat carcinoma 256. Lesser activity is shown against the Novikoff hepatoma and the primary benzpyrene tumour. The compound has little or no activity against the rat Yoshida sarcoma or the ADJ/PC6A mouse plasma cell tumour, the growth of which is considerably inhibited by difunctional alkylating agents of the nitrogen mustard gas type. The effects on the haematopoietic system are not unduly severe and the pathological effects at the minimum toxic dose are manifest in the liver and urinary tract. |
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