翡翠贻贝多糖对衰老模型小鼠的抗氧化和免疫功能调节作用

目的观察翡翠贻贝多糖(PVPS)对D-半乳糖致衰老模型小鼠的抗氧化和免疫功能调节作用。方法小鼠背部皮下注射D-半乳糖建立衰老模型,同时给药组灌服高、中、低3个剂量的PVPS溶液,6周后检测各组小鼠超氧化物歧化酶(SOD)、丙二醛(MDA)、谷胱甘肽过氧化物酶(GSH-PX)、白细胞介素2(IL-2)、γ干扰素(IFN-γ)、脾淋巴细胞增殖反应刺激指数等抗氧化和免疫功能指标。结果衰老模型小鼠血清和脑组织SOD、GSH-PX,血清IL-2、IFN-γ和及脾淋巴细胞增殖反应率均显著性降低,同时血清MDA水平显著性升高差异有统计学意义(P0.01)。PVPS各剂量组均可不同程度地升高SOD、GSH-PX、IL-2、IFN-γ和脾淋巴细胞增殖反应率,同时降低MDA水平差异有统计学意义(P0.05或P0.01)。结论 PVPS具有抗衰老作用,其机制可能与提高机体抗氧化酶活力和免疫功能有关。

Effect of Perna viridis polysaccharides on antioxidation and immune function of aging model mice

Objective To explore the effect of Perna viridis polysaccharides（PVPS）on the antioxidation and immune function of aging model mice.Methods To set up the aging model of mice by subcutaneous injection of D-galactose,meanwhile,the medication administration group was given the high,medium and low dose of PVPS.After 6 weeks,the indexes of antioxidation and immune function including SOD,MDA,GSH-PX,IL-2,IFN-γ and stimulation index（SI）of spleen lymphproliferation response were determined.Results The content of SOD,GSH-PX,IL-2,IFN-γ and spleen lymphproliferation response were reduced obviously in aging model mice,but the content of MDA increased a lot（P〈0.01）.The each dose group of PVPS ould increase the content of SOD,GSH-PX,IL-2,IFN-γ and spleen lymphproliferation response in varying degrees（P〈0.05 or P〈0.01）.Conclusion PVPS has the anti-aging function,it is maybe related to the enhancement of antioxidase activity and immune function.