| 盐酸甜菜碱制备工艺的改进 |
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| 引用本文： | 郝立勇,汪海,杜江山,齐永秀,朱晓慧.盐酸甜菜碱制备工艺的改进[J].中国医药工业杂志,2002,33(9):428-428. |
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| 作者姓名： | 郝立勇 汪海 杜江山 齐永秀 朱晓慧 |
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| 作者单位： | 1. 泰山医学院药学系
2. 泰山医学院工程学院,山东泰安,271000 |
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| 摘 要： | 用氢氧化钙中和氯乙酸，制得的氯乙酸钙经与过量三甲胺反应、盐酸酸化生成盐酸甜菜碱的氯化钙水溶液，经过滤、浓缩、冷却，制得盐酸甜菜碱。以氯乙酸计收率91％。
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| 关 键 词： | 盐酸甜菜碱 制备工艺 氯乙酸钙 三甲胺 利胆药 |
| 文章编号： | 1001-8255(2002)09-0428-01 |
| 修稿时间： | 2002年2月9日 |
Improved Preparation of Betaine Hydrochloride |
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| Authors: | HAO Li Yong WANG Hai DU Jiang Shan QI Yong Xiu ZHU Xiao Hui |
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| Institution: | HAO Li Yong 1,WANG Hai 2,DU Jiang Shan 2,QI Yong Xiu 1,ZHU Xiao Hui 2 |
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| Abstract: | Betaine hydrochloride was synthesized from calcium chloroacetate,which from chloroacetic acid by neutralising with calcium hydroxide, and reacted with excess trimethylamine and acidified with hydrochloric acid to form salt (CaCl 2) solution, then via filtration, concentration and cooling with an overall yield of 91% (base on chloroacetic acid). |
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| Keywords: | betanine hydrochloride calcium chloroacetate trimethylamine |
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