Comparison of immunotoxic effects induced by the extracts from methanol and gasoline engine exhausts in vitro |
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Institution: | 1. Kunming Center for Disease Control and Prevention, No. 4, Ziyun Road, Kunming 650228, China;2. Department of Environmental Health, West China College of Public Health, Sichuan University, No. 16, Section 3, Renminnan Road, Chengdu 610041, China;3. Yunnan Provincial Center for Disease Control and Prevention, No.158, Dongsi Street, Kunming 650022, China;4. Mianyang Center for Disease Control and Prevention, No. 62, Fucheng Road, Mianyang 621000, China |
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Abstract: | Gasoline engine exhaust has been considered as a major source of air pollution in China. Due to lower cyto- and geno-toxicity effects of methanol engine exhaust, methanol is regarded as a potential substitute for gasoline. We have previously compared cyto- and geno-toxicities of gasoline engine exhaust with that of methanol engine exhaust in A549 cells (Zhang et al., 2007).To characterize the immunotoxic effects for gasoline and methanol engine exhausts in immune cell, in this study, we further compared effects of gasoline and methanol engine exhausts on immune function in RAW264.7 cell and rabbit alveolar macrophages. Results showed that both gasoline and methanol engine exhaust could evidently inhibit RAW264.7 cell proliferation, promote RAW264.7 cell apoptosis, decrease E-rosette formation rate and inhibit anti-tumor effects of alveolar macrophages, at the same time, these effects of gasoline engine exhaust were far stronger than those of methanol engine exhaust. In addition, gasoline engine exhaust could significantly inhibit activities of ADCC of alveolar macrophages, but methanol engine exhaust could not. These results suggested that both gasoline and methanol engine exhausts might be immunotoxic atmospheric pollutants, but some effects of gasoline engine exhaust on immunotoxicities may be far stronger than that of methanol engine exhaust. |
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Keywords: | Immunotoxicity Gasoline engine exhaust Methanol engine exhaust RAW264 7 cell Alveolar macrophages Rabbit |
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