Consanguineous marriages,pearls and perils: Geneva International Consanguinity Workshop Report |
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| Institution: | 1. Department of Genetic Medicine and Development, University of Geneva Medical School, and University Hospitals of Geneva, Geneva, Switzerland;2. Stanford University Medical School, Center of Human Population Genetics, Institute of Molecular Genetics of the Italian National Research Council, University of Pavia, Milano, Italy;3. Human Genetics and Genome Research Division, Clinical Genetics Department, National Research Centre, Cairo, Egypt;4. University of Bologna Medical School, Italy;5. VU University Medical Center, Amsterdam, The Netherlands;6. Department of Medicine, University of Washington Medical Center, Medical Genetics, Seattle, Washington;7. Ethox Centre, Department of Public Health, University of Oxford, United Kingdom, Oxford, United Kingdom;8. Medical Genetics Unit and Laboratoire Associe´ INSERM UMR_S910, Saint Joseph University; Beirut, Lebanon;9. Department of Epidemiology and Biostatistics, Erasmus University Medical School, Erasmusmc, Rotterdam, The Netherlands;10. Department of Reproductive Health and Research, World Health Organization, Geneva, Switzerland;11. Hebrew University Jerusalem, Department of Community Genetics, Public Health services, Ministry of Health, Israel;12. Department of Genetic and Laboratory Medicine, Geneva University Hospital, Geneva, Switzerland;13. Génome Québec and Ecogene-21 Biobank, Chicoutimi, Quebec, Canada;14. Institute for Health Research, University of Bedfordshire, Bedfordshire, United Kingdom;15. Mental Health Section, PHC Department/Ministry of Health, Baghdad, Iraq;16. University Diabetes Center, King Saud University, Riyadh, Saudi Arabia;17. Aziziah Maternity and Children Hospital, Ministry of Health, Jeddah, Saudi Arabia;18. Department of Obstetrics and Gynecology, Medical City, Baghdad, Iraq;19. Hadassah University Medical Center, Jerusalem, Israel;20. King’s College, London, University of Oxford, United Kingdom;21. Child Development Centre, Bradford Teaching Hospitals NHS Foundation Trust, United Kingdom;22. The Leeds Teaching Hospitals, NHS Trust, Yorkshire Regional Genetic Service, Department of Clinical Genetics, Leeds, United Kingdom;23. Laboratorio di Genetica Medica, Dipartimento di Scienze Ginecologiche, Ostetriche Pediatriche-Universita` di Bologna, Policlinico S. Orsola-Malpighi, Bologna, Italy;24. Laboratory of Human Embryology, Institute of Medical Biology, A*STAR, Singapore;25. Leeds Teaching Hospitals, Department of Clinical Genetics, Chapel Allerton Hospital, Leeds, United Kingdom;26. VU University Medical Center, Department of Clinical Genetics and EMGO Institute for Health and Care Research, Amsterdam, The Netherlands;27. Centre for Comparative Genomics, Murdoch University, and Edith Cowan University, Perth, Western Australia, Australia |
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| Abstract: | Approximately 1.1 billion people currently live in countries where consanguineous marriages are customary, and among them one in every three marriages is between cousins. Opinions diverge between those warning of the possible health risks to offspring and others who highlight the social benefits of consanguineous marriages. A consanguinity study group of international experts and counselors met at the Geneva International Consanguinity Workshop from May 3 2010, to May 7, 2010, to discuss the known and presumptive risks and benefits of close kin marriages and to identify important future areas for research on consanguinity. The group highlighted the importance of evidence-based counseling recommendations for consanguineous marriages and of undertaking both genomic and social research in defining the various influences and outcomes of consanguinity. Technological advances in rapid high-throughput genome sequencing and for the identification of copy number variants by comparative genomic hybridization offer a significant opportunity to identify genotype-phenotype correlations focusing on autozygosity, the hallmark of consanguinity. The ongoing strong preferential culture of close kin marriages in many societies, and among migrant communities in Western countries, merits an equivalently detailed assessment of the social and genetic benefits of consanguinity in future studies. |
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