Long-Term Cancer-Free Survival after Infusion of Autologous Cord Blood Cells for Rejection-Unrelated Cord Blood Graft After Myeloablative Conditioning for t-MDS: A Case Report |
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| Authors: | Wei-Ting Chen Li-Hua Fang Rong-Long Chen |
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| Affiliation: | From the Departments of Internal Medicine (W-TC); Pharmacy (L-HF); and Pediatric Hematology and Oncology (R-LC), Koo Foundation Sun Yat-Sen Cancer Center, Taipei, Taiwan. |
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| Abstract: | Autologous cord blood transplantations are rarely applied in patients with hematologic as well as metastatic solid cancers since contamination of malignant clones is a concern.We report a case of therapy-related myelodysplasia after metastatic neuroblastoma who suffered from graft rejection and life-threatening infections after a myeloablative unrelated cord blood transplantation.The patient experiences long-term survival, free from leukemia/neuroblastoma after infusion of autologous cord blood cells.It suggests that autologous cord blood transplantation after high dose therapy might be a curative strategy for certain hematologic or metastatic solid cancers. |
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