Differential gene expression in a rat model of depression based on persistent differences in exploratory activity |
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| Institution: | 1. Department of Psychology, Estonian Centre of Behavioural and Health Sciences, University of Tartu, Tiigi 78, 50410 Tartu, Estonia;2. Department of Computer Science, University of Manchester, Manchester M13 9PL, United Kingdom;1. New York State Psychiatric Institute and Columbia University College of Physicians and Surgeons, New York, NY, USA;2. James J. Peters Veterans'' Administration Medical Center and Icahn School of Medicine at Mount Sinai, 130 West Kingsbridge Road, Bronx, New York, NY, USA;1. Departments of Aerospace & Mechanical Engineering and Materials Science, University of Southern California, Los Angeles, CA 90089-1453, USA;2. Material Measurement Laboratory, National Institute of Standards and Technology, Gaithersburg, MD 20899-8553, USA;3. Advanced Photon Source, Argonne National Laboratory, Argonne, IL 60439-4800, USA;4. Materials Research Group, Faculty of Engineering and the Environment, University of Southampton, Southampton SO17 1BJ, UK;1. Graduate School of Sports and Health Science, Fukuoka University, Fukuoka, Japan;2. Faculty of Sports and Health Science, Fukuoka University, Fukuoka, Japan |
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| Abstract: | Affective disorders are often accompanied by changes in motivation and anxiety. We investigated the genome-wide gene expression patterns in an animal model of depression that separates Wistar rats belonging into clusters of persistently high anxiety/low motivation to explore and low anxiety/high motivation to explore (low explorers and high explorers, LE and HE, respectively), in three brain regions previously implicated in mood disorders (raphe, hippocampus and the frontal cortex). Several serotonin-, GABA-, and glutamatergic genes were differentially expressed in LE- and HE-rats. The analysis of Gene Ontology biological process terms associated with the differentially regulated genes identified a significant overrepresentation of genes involved in the neuron development, morphogenesis, and differentiation; the most enriched pathways from the Kyoto Encyclopedia of Genes and Genomes were the Wnt signalling, MAPK signalling, long-term potentiation, and long-term depression pathways. These findings corroborate some expression data from other models of depression, and suggest additional targets. |
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