Meta-analysis of BDNF Val66Met polymorphism association with treatment response in patients with major depressive disorder |
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| Institution: | 1. Hospital de Clínicas de Porto Alegre, Department of Psychiatry, Porto Alegre, Brazil;2. Universidade Federal do Rio Grande do Sul (UFRGS), Department of Psychiatry and Forensic Medicine, Programa de Pós-Graduação Ciências Médicas: Psiquiatria, Porto Alegre, Brazil;3. Hospital São Lucas da Pontifícia Universidade Católica do Rio Grande do Sul (PUCRS), Department of Psychiatry, Porto Alegre, Brazil;4. Universidade Federal do Rio Grande do Sul (UFRGS), Programa de Pós-Graduação em Ciências Biológicas: Bioquimica, Porto Alegre, RS, Brazil;5. Department of Psychiatry, Massachusetts General Hospital, Boston, MA, USA;6. Harvard Medical School, Boston, MA, USA;1. University of Groningen, Groningen Research Institute of Pharmacy, Unit of PharmacoTherapy, Epidemiology & Economics, Antonius Deusinglaan 1, 9713AV Groningen, the Netherlands;2. Mental Health Research Institute, Tomsk National Research Medical Center of the Russian Academy of Sciences, Aleutskaya street, 4, 634014 Tomsk, Russian Federation;3. National Research Tomsk State University, Department of Psychotherapy and Psychological Counseling, Lenin Avenue, 36, 634050 Tomsk, Russian Federation;4. GGZ Westelijk Noord-Brabant, Hoofdlaan 8, 4661AA Halsteren, the Netherlands;5. University of Groningen, University Medical Centre Groningen, University Centre for Psychiatry, Hanzeplein 1, 9713 GZ Groningen, PO Box 30.001, 9700 RB Groningen, the Netherlands;6. Siberian State Medical University, Moscowski Trakt, 2, 634050, Tomsk, Russian Federation;7. University of Groningen, University Medical Center Groningen, Department of Clinical Pharmacy and Pharmacology, Hanzeplein 1, 9713 GZ Groningen, PO Box 30.001, 9700 RB Groningen, the Netherlands;8. National Research Tomsk Polytechnic University, School of Non-Destructive Testing & Security, Division for Control and Diagnostics, Lenin Avenue, 30, 634050 Tomsk, Russian Federation |
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| Abstract: | The aim of our meta-analysis was to assess the association between BDNF Val66Met polymorphism and treatment response in patients with MDD. 8 studies that included data from 1115 subjects were identified. We tested two phenotypes: response rate and remission rate. OR was used as a measure of the effect of the association in a fixed/random effect model. Meta-analysis was performed for genotypes Met/Met versus Val/Val, Val/Met versus Val/Val, Met/Met versus Val/Met, Val/Met + Met/Met versus Val/Val, Met/Met versus Val/Val + Val/Met, and Met allele versus Val allele. When all groups were pooled, a significant association of Val/Met genotype and increased response rate was found in comparison to Val/Val in overall population (OR = 1.66, 95%CI = 1.07–2.57, P = 0.02). In the subgroup analysis, similar result was shown in Asian population (OR = 1.83, 95%CI = 1.03–3.26, P = 0.04), but not in Caucasian population. We didn't observe a significant association of BDNF Val66Met polymorphism with remission rate. This meta-analysis demonstrates the association between BDNF Val66Met polymorphism and treatment response in patients with MDD, and Val66Met heterozygous patients have a better response rate in comparison to Val/Val homozygote patients, especially in Asian population. |
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