| 血管紧张素Ⅰ转换酶基因多态性与NIDDM并发高血压的相关性研究 |
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| 引用本文： | 鲁严,邓振霞.血管紧张素Ⅰ转换酶基因多态性与NIDDM并发高血压的相关性研究[J].中国优生与遗传杂志,1999,7(3):23-24. |
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| 作者姓名： | 鲁严 邓振霞 |
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| 作者单位： | 江苏省无锡市第一人民医院中心实验室 |
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| 摘 要： | 目的：研究血管紧张素Ⅰ转换酶（ＡＣＥ）基因与非胰岛素依赖型糖尿病（ＮＩＤＤＭ）合并高血压的关系。方法：采用ＰＣＲ方法观察１５９例ＮＩＤＤＭ（包括７８例合并高血压病人的ＡＣＥ基因多态性。结果：ＡＣＥ基因多态性分析显示：ＮＩＤＤＤＭ合并高血压患者ＤＤ基因型明显高于合并高血压者（Ｐ＜０．０５）。结论：ＡＣＥ基因多态性可作为一种标志，提示ＤＤ基因型与ＮＩＤＭ合并高血压的发生有关，Ｉ型可能为保护性基因。
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| 关 键 词： | 血管紧张素I转换酶（ACE）基因 NIDDM 基因多态性 高血压 PCR |
Association of ACE gene polymorphism with hypertention in NIDDM. |
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| Lu Yan,Xu Yang,Deng Zhenxia,et al..Association of ACE gene polymorphism with hypertention in NIDDM.[J].Chinese Journal of Birth Health & Heredity,1999,7(3):23-24. |
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| Authors: | Lu Yan Xu Yang Deng Zhenxia |
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| Abstract: | Objective:To investigate the association of polymorphism of Angiotensin I converting enzyme (ACE) gene with hypertension in NIDDM.Methods:Study of ACE Gene in 159 cases of NIDDM (78 with hypertension and 81 without hypertension)and 150 controls by ploymerase chain reaction.Results:It was found that the DD genotype was significantly higher in hypertensive NIDDM than in normotensive NIDDM (p<0.01),while the II genotype was much less in hypertensive group.Conclusion:ACE Gene is associated with Chinese hypertensive NIDDM.As a marker ACE polymorphism suggests that DD genotype is possibly involved in the development of hypertension in NIDDM,while II is a protective genotype. |
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| Keywords: | Diabetes mellitus Noninsulindependent Hypertension Angiotensin I converting enzyme gene (Original artical on page 23) |
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