Hypereosinophilic syndrome in Hodgkin's disease with increased granulocyte-macrophage colony-stimulating factor |
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Authors: | M. Endo K. Usuki K. Kitazume K. Iwabe Y. Okuyama A. Urabe |
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Affiliation: | (1) Division of Hematology, Kanto Teishin Hospital, 5-9-22 Higashigotanda, Shinagawa-ku, 141 Tokyo, Japan |
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Abstract: | We report a patient with eosinophilia accompanied by Hodgkin's disease who showed remarkable increase in granulocyte-macrophage colony-stimulating factor (GM-CSF) in plasma but no increase in interleukin-5 (IL-5). The plasma GM-CSF level normalized as eosinophilia and lymphadenopathy disappeared after chemotherapy. Immunohistochemical study with immunoperoxidase staining technique showed a positive stain in lymph node cells by monoclonal anti-GM-CSF antibody. Eosinophilia is often accompanied by Hodgkin's disease, and several cases have been reported to show high levels of plasma IL-5. To our knowledge, this is the first report to show a high level of plasma GM-CSF in Hodgkin's disease with eosinophilia. |
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Keywords: | Hodgkin's disease IL-5 GM-CSF Eosinophilia |
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