| 动脉粥样硬化病变中黏附分子ICAM-1、VCAM-1及E-selectin的表达 |
| |
| 引用本文： | 苏敏,钟翠平.动脉粥样硬化病变中黏附分子ICAM-1、VCAM-1及E-selectin的表达[J].第三军医大学学报,2009,31(11). |
| |
| 作者姓名： | 苏敏 钟翠平 |
| |
| 作者单位： | 1. 贵阳医学院组织胚胎学教研室,贵阳,550004
2. 复旦大学上海医学院人体解剖与组织胚胎学系,上海,200032 |
| |
| 摘 要： | 目的 研究动脉粥样硬化主动脉管壁内ICAM-1、VCAM-1及E-selectin的表达情况,探讨这些分子与动脉粥样硬化发生及彼此之间可能的关系.方法 收集尸检证实主动脉粥样硬化的标本,常规石蜡切片,特异性免疫组化染色,观察ICAM-1、VCAM-1和E-selectin阳性反应细胞的数量及分布,测定阳性产物表达的平均灰度值.结果 ICAM-1、VCAM-1、E-selectin阳性细胞主要分布在动脉粥样硬化主动脉内膜及外膜内,阳性细胞数较正常主动脉明显增多(P＜0.01);阳性产物的平均灰度值与正常主动脉相比明显降低(P＜0.01);ICAM-1阳性反应产物的平均灰度值变化与VCAM-1及E-selectin之间旱显著正相关(r=0.611,r=0.718,P＜0.01),VCAM-1阳性反应产物的平均灰度值变化与E-selectin之间呈显著正相关(r=0.728,P＜0.01).结论 黏附分子ICAM-1、VCAM-1、E-selectin参与了动脉粥样硬化病变形成的过程.
|
| 关 键 词： | 动脉粥样硬化 细胞间黏附分子-1 血管细胞黏附分子-1 E-选择素 |
Expressions of ICAM-1,VCAM-1 and E-selectin in artherosclerosis aorta |
| |
| SU Min,ZHONG Cui-ping.Expressions of ICAM-1,VCAM-1 and E-selectin in artherosclerosis aorta[J].Acta Academiae Medicinae Militaris Tertiae,2009,31(11). |
| |
| Authors: | SU Min ZHONG Cui-ping |
| |
| Institution: | SU Min1,ZHONG Cui-ping2(1Department of Histology and Embryology,Guiyang Medical College,Guiyang 550004,2Faculty of Anatomy,Histology and Embryology,Shanghai Medical School,Fudan University,Shanghai 200032,China) |
| |
| Abstract: | Objective To study the expressions of intercellular adhesion molecule-1(ICAM-1),vascular cell adhesion molecule-1(VCAM-1) and E-selectin on the aorta of artherosclerosis and explore the relationship between these molecules and artherosclerosis(AS).Methods Human arterial specimens were collected from 18 cadavers,including 5 with normal arterial tunica intima(control) and 13 with pathologically identified AS(AS group).Analysis were carried out in consecutive sections by immunohistochemical staining for ICAM-1... |
| |
| Keywords: | artherosclerosis intercellular adhesion molecule-1 vascular cell adhesion molecule-1 E-selectin |
| 本文献已被 CNKI 万方数据 等数据库收录！ |
|
