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| 癫痫发作过程海马区脑源性神经营养因子及其相关蛋白的变化 | |
| 引用本文： | 罗向阳,黄绍良,李海刚,黎福荣,何展文,岑丹阳. 癫痫发作过程海马区脑源性神经营养因子及其相关蛋白的变化[J]. 中国病理生理杂志, 2004, 20(3): 452-455 |
| 作者姓名： | 罗向阳 黄绍良 李海刚 黎福荣 何展文 岑丹阳 |
| 作者单位： | 1. 中山大学孙逸仙纪念医院 儿科, 广东 广州 510120; 2. 中山大学孙逸仙纪念医院 病理科, 广东 广州 510120; 3. 中山大学医学院实验动物中心, 广东 广州 510089 |
| 摘 要： | 目的:探讨脑源性神经营养因子(BDNF)与癫痫发作的关系。方法:将听源性癫痫鼠分成安静期、惊厥前期、惊厥期及惊厥后期4组,用免疫组织化学方法检测在惊厥不同阶段脑内海马区BDNF及相关蛋白,用图像分析仪比较各蛋白的阳性单位(PU)。Wistar大鼠作对照。结果:听源性癫痫鼠安静期BDNF显著低于对照组,受刺激兴奋后的惊厥前期、惊厥期及惊厥后期BDNF增高并略高于对照组;而BDNF受体(trkB)的表达在各阶段均增高,作为trkB激活的标志蛋白磷酸化酪氨酸(PY20)只在受刺激兴奋后的惊厥前期和惊厥期增高;具抑制性作用的神经肽(NPY)在惊厥前均处于低水平。结论:内源性BDNF可能分别通过调控NPY和激活受体trkB两个途径影响听源性癫痫鼠的神经兴奋性。 |
| 关 键 词： | 癫痫 脑源性神经营养因子 神经肽Y |
| 文章编号： | 1000-4718(2004)03-0452-04 |
| 收稿时间： | 2002-10-23 |
| 修稿时间： | 2003-02-28 |
Changes of the BDNF in the hippocampus of P77PMC during seizures |
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| LUO Xiang-yang,HUANG Shao-liang,LI Hai-gang,LI Fu-rong,HE Zhan-wen,CEN Dan-yang. Changes of the BDNF in the hippocampus of P77PMC during seizures[J]. Chinese Journal of Pathophysiology, 2004, 20(3): 452-455 | |
| Authors: | LUO Xiang-yang HUANG Shao-liang LI Hai-gang LI Fu-rong HE Zhan-wen CEN Dan-yang |
| Affiliation: | 1. Department of Pediatrics, Sun Yat-sen Memorial Hospital, Zhoushan University, Guangzhou 510120, China; 2. Department of Pathlogy, Sun Yat-sen Memorial Hospital, Zhoushan University, Guangzhou 510120, China; 3. Center of Experimental Animals, Sun Yat-sen Medical College, Zhongshan University, Guangzhou 510089, China |
| Abstract: | AIM: To quest the relationship bwteen BDNF and seizures. METHODS: BDNF and other correlative proteins in the hippocampus of audioepileptic rat (P77PMC) have been detected by immunohistochemistry at different stages of seizures including quiet stage, preconvulsive stage, convulsive stage and postconvulsive stage. Wistar rats were served as controls. RESULTS: At quiet stage, the BDNF in the hippocampus of P77PMC were less than that of control group and stepped up after stimulation, trkB in the hippocampus of P77PMC were high at every stages, but PY20 were increased only after stimulation. NPY in the hippocampus of P77PMC were in a low level before seizures. CONCLUSION: The endogenetic BDNF may alter the excitement of P77PMC by adjusting the expression of NPY in hippocampus and activating its receptor trkB. |
| Keywords: | Epilepsy Brain-derived neurotrophic factor Neumpeptide Y |
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