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Gender dependent effect of DHCR24 polymorphism on the risk for Alzheimer's disease |
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| Authors: | Ágnes Fehér Anna JuhászMagdolna Pákáski János KálmánZoltán Janka |
| Institution: | University of Szeged, Department of Psychiatry, Szeged, Hungary |
| Abstract: | A remarkable candidate gene for late-onset Alzheimer's disease (AD) is 24-dehydrocholesterol reductase (DHCR24) gene that encodes seladin-1 (selective AD indicator), an enzyme that is involved in the cholesterol biosynthetic pathway, exerts neuroprotective and anti-apoptotic effects, and found to be down regulated in AD vulnerable brain regions. |
| Keywords: | Alzheimer's disease 24-Dehydrocholesterol reductase (DHCR24) Seladin-1 (selective AD indicator) Single nucleotide polymorphism (SNP) rs600491 Apolipoprotein E4 (APOE) |
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