Antinociceptive effects induced by injection of the galanin receptor 1 agonist M617 into central nucleus of amygdala in rats |
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Authors: | Jun Li Jian Jun Zhang Shi-Lian Xu Long-Chuan Yu |
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Institution: | 1. State Key Laboratory of Biomembrane and Membrane, Biotechnology and Neurobiology Laboratory, College of Life Sciences, Peking University, Beijing 100871, PR China;2. Kunming Medical University, Kunming 650000, PR China |
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Abstract: | The present study was performed to explore the antinociceptive effects of M617, a selective galanin receptor 1 agonist, in the central nucleus of amygdala (CeA) of rats. Intra-CeA injection of 0.1 nmol, 0.5 nmol and 1 nmol of M617 induced dose-dependent increases in hindpaw withdrawal latencies (HWLs) to noxious thermal and mechanical stimulations in rats. Furthermore, rats received intra-CeA administration of M617 and galanin. The HWL to noxious thermal and mechanical stimulations increased markedly, and there were no significant differences in HWLs of rats received intra-CeA administration of M617 and galanin. The results demonstrated that intra-CeA injection of M617 induced significant antinociceptive effects in CeA of rats, indicating that galanin receptor 1 may be involved in M617-induced antinociception in the CeA of rats. |
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Keywords: | Antinociceptive effect The central nucleus of amygdala Galanin Galanin receptor 1 Hindpaw withdrawal latency M617 |
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