Sarcomas as a mise en abyme of mesenchymal stem cells: Exploiting interrelationships for cell mediated anticancer therapy |
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| Authors: | Jorge S Burns Akmal Safwat Giulia Grisendi Moustapha Kassem Massimo Dominici |
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| Institution: | 1. Laboratory of Cell Biology and Advanced Cancer Therapies, Department of Oncology, Hematology and Respiratory Disease, University Hospital of Modena and Reggio Emilia, Modena, Italy;2. Department of Oncology, Aarhus University Hospital, Aarhus, Denmark;3. Oncology Department, College of Medicine, King Saud University, Riyadh, KSA, Saudi Arabia;4. Laboratory for Molecular Endocrinology, Odense University Hospital, Odense, Denmark;5. Stem Cell Unit, Department of Anatomy, College of Medicine, King Saud University, Riyadh, KSA, Saudi Arabia |
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| Abstract: | Mise en abyme meaning “placed into abyss or infinite recurrence” is an apt paradigm for the relentless growth of sarcoma cells. Its alternative meaning, “self-reflexive embedding” fits the central role attributed to cancer stem cells (CSCs). Diversely sourced and defined, mesenchymal stem cells (MSCs) may be the cells of sarcoma origin, evolve a CSC phenotype and/or contribute to tumor growth through inherent qualities for homing, neovascularization, paracrine cross-feeding, microvesicle secretion, cell fusion, entosis and immune modulation. Exploiting these qualities, MSC expressing modified forms of the TNF-related apoptosis-inducing ligand (Apo2L/TRAIL) are being developed to complement more conventional radiation and chemotherapy. |
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| Keywords: | Sarcoma Mesenchymal stem cell Cell therapy Radiation TRAIL |
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