Involvement of P2Y13 receptor in suppression of neuronal differentiation |
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| Authors: | Shinya Yano Mitsutoshi Tsukimoto Hitoshi Harada Shuji Kojima |
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| Affiliation: | 1. Department of Radiation Biosciences, Faculty of Pharmaceutical Sciences, Tokyo University of Science (TUS), 3613 Yamazaki, Noda City, Chiba 278-8510, Japan;2. Faculty of Pharmaceutical Sciences, Suzuka University of Medical Science, 3500-3 Minamitamagaki, Suzuka-Shi, Mie 513-0816, Japan |
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| Abstract: | We examined the receptor-mediated effects of extracellular ATP on neuronal differentiation of PC12 cells, Neuro2a cells and MEB5 cells by using a series of receptor antagonists. The P2Y13 receptor antagonist MRS2211 significantly accelerated neurite outgrowth in all cases. Treatment with nerve growth factor (NGF) alone activated ERK1/2 in PC12 cells, and the activation was further increased by MRS2211. These results suggest involvement of P2Y13 receptor in suppression of neuronal differentiation. Thus, P2Y13 receptor antagonists might be candidates for treatment of neurodegenerative diseases. |
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| Keywords: | PC12 Neuronal differentiation Purinergic signaling P2Y13 |
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