Inflammation of temporomandibular joint increases neural activity in rat vestibular nucleus |
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Authors: | Sung-Won Chung Myeung Ju Kim Jin-Chul Ahn Myung-Whan Suh Chung-Ku Rhee Jae Yun Jung |
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Institution: | 1. Department of Otolaryngology-Head & Neck Surgery, College of Medicine, Dankook University, Cheonan, Republic of Korea;2. Department of Anatomy, College of Medicine, Dankook University, Cheonan, Republic of Korea;3. Medical Laser Research Center, College of Medicine, Dankook University, Cheonan, Republic of Korea |
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Abstract: | To determine whether the vestibular nuclei are affected by inflammation of temporomandibular joint (TMJ) region, we studied vestibular nucleus neural activity using two experimental groups: (1) normal saline 0.1 cm3 injection at right TMJ region, (2) 10% formalin 0.1 cm3 injection at right TMJ region. Neural activity after 24 hours was assessed by immunohistochemical staining with free-floating section at the level of interaural −1.30 mm to −2.00 mm for c-Fos. In inflammation group, formalin injection produced a bilateral increase in c-Fos at vestibular nucleus with ipsilesional side higher activity. In control group, expression of c-Fos protein was also observed in the vestibular nucleus (VN), especially MVN. But stain intensity of Fos-positive neurons was much weaker and mean number of c-Fos positive cells was fewer than inflammation group. This result suggests that there is a close neural connection between TMJ and vestibular nucleus, especially in case of inflammation. |
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Keywords: | Trigemino-vestibular pathway Vertigo Connection |
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