Vitamin D receptor gene polymorphism and its association with Parkinson's disease in Chinese Han population |
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Authors: | Xun Han Li Xue Yongsheng Li Biao Chen Anmu Xie |
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Affiliation: | 1. Department of Neurology, Affiliated Hospital of Medical College, Qingdao University, Qingdao, China;2. Department of Rehabilitation, Affiliated Hospital of Medical College, Qingdao University, Qingdao, China;3. Department of Neurology, Beijing Xuanwu Hospital, Chinese Human Genetic Center, Beijing, China |
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Abstract: | Vitamin D plays an important role in neurodegenerative disorders as a crucial neuro-immunomodulator, and accumulating data have provided evidence for that vitamin D receptor (VDR) gene is a candidate gene for susceptibility to Parkinson's disease (PD). In this study, we performed a case-control study to demonstrate whether the risk for the development of onset of sporadic PD might be influenced by VDR gene polymorphisms in a Chinese cohort. Two hundred and sixty PD patients and 282 matched-healthy controls were genotyped for two representative single nucleotide polymorphisms (SNPs) in VDR gene (FokI C/T and BsmI G/A) by polymerase chain reaction and restriction fragment length polymorphism (PCR-RFLP) analysis in. Results from our study revealed that FokI C allele carriers were likely to associate with an increased risk of PD (P = 0.004) as well as early-onset PD (EOPD) (P = 0.010). Moreover, the frequency of FokI C allele was significantly increased in PD group and late-onset PD (LOPD) group relative to the control groups respectively (P = 0.023 and P = 0.033, respectively). For BsmI polymorphisms, no significant difference in genotype or allele distribution was found between PD patients and the controls, as well as gender- and age-related differences between PD patients and the controls subgroup. This study demonstrated a possible association between the VDR FokI T/C polymorphism and PD, indicating that VDR polymorphisms may well change genetic susceptibility to sporadic PD in a Han Chinese population. |
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Keywords: | Vitamin D receptor (VDR) Parkinson's disease (PD) Polymorphism |
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