胃癌中RhoC和CD44v6及ICAM-1的表达及其相关性的初步研究

目的探讨RhoC、CD44v6和ICAM-1在胃癌中的表达及其相关性。方法应用免疫组织化学SABC法检测RhoC、CD44v6和ICAM-1在40例胃癌组织的表达情况,结合其临床病理学资料,分析它们之间的相关性。结果RhoC、CD44v6和ICAM-1的表达与肿瘤细胞分化、浸润深度无关(P>0.05),但与淋巴结转移、PTNM分期具有相关性(P<0.05)。RhoC与CD44v6和ICAM-1的表达存在相关性(分别为r=0.355,P=0.006;r=0.354,P=0.003)。当RhoC为阳性,CD44v6和ICAM-1两者之一为阳性时,对预测胃癌淋巴结转移的灵敏性和特异性分别为93.8%和62.5%。结论RhoC、CD44v6和ICAM-1的阳性表达预示胃癌具有较强的侵袭转移能力,可作为预测胃癌转移潜能的生物学指标。联合检验以上3种指标有望成为预测胃癌淋巴结转移的又一种有价值的手段。

Expressions of RhoC,CD44v6 and ICAM-1 in human gastric cancer and its clinicopathological significance

Objective To investigate the expressions of RhoC,CD44v6 and ICAM- 1 in gastric cancer and their correlations. Methods SABC immunohistochemistry was used to detect the expressions of RhoC,CD44v6 and ICAM- 1 in the specimens from 40 cases with gastric cancer. Their correlations were reviewed by clinicopathological data. Results The expression of RhoC,CD44v6 and ICAM- 1 were not correlated with tumor differetiation and invasion depth(P >0.05),but significantly correlated with lymph metastasis and pTNM stage(P< 0.05). There was a significant correlation between the expression of RhoC and the expression of CD44v6 or ICAM- 1( r=0.355, P=0.006;r=0.354, P=0.003) respectively. If RhoC was positive- expressed,and either of CD44v6 or ICAM- 1 was positive- expressed, the sensitivity and the specificity for predicting the lymphatic metastasis was 93.75% ,62.5% respectively. Conclusions The positive expressions of RhoC,CD44v6 and ICAM- 1 are useful biological markers for predicting the metastatic potential of gastric cancer. The combined detection of three markers is a useful method for predicting lymphatic metastasis of gastric cancer.