| 潜阳合剂对自发性高血压大鼠血压及心、肾重量的影响 |
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| 引用本文： | 刘春,蒋梅先. 潜阳合剂对自发性高血压大鼠血压及心、肾重量的影响[J]. 河南中医学院学报, 2011, 26(1) |
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| 作者姓名： | 刘春 蒋梅先 |
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| 作者单位： | 河南中医学院第三附属医院;上海中医药大学附属曙光医院; |
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| 基金项目： | 上海市市属博士学科点建设基金项目(编号:20080246404) |
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| 摘 要： | 目的:观察潜阳合剂(QYHJ)干预自发性高血压大鼠(SHR)的降压作用和对心、肾质量指数的影响。方法:77日龄雄性SHR 40只随机分为5组:QYHJ高、中、低剂量3组、福辛普利组和SHR对照组,并设77日龄WKY大鼠8只为WKY对照组和21日龄SHR8只为QYHJ幼龄对照组。用药前及用药后每14 d均以鼠尾测压法测量血压,各测3次取平均值。140日龄时处死大鼠,测量全心、左右心室、双侧肾脏的质量,计算全心、左右心室、双侧肾脏的质量指数。结果:SHR血压较WKY大鼠明显增高(P<0.001),心、肾质量指数增加(P<0.001);大鼠血压与CMI、LVMI、KMI呈正相关(P<0.001,P<0.01),与RVMI无明显相关性。药物干预后,QYHJ高、中剂量组血压均明显降低(P<0.001),QYHJ幼龄组血压稳定降低(P<0.001);QYHJ低剂量组血压无明显变化。QYHJ 4组LVMI均明显较SHR对照组减小,QYHJ高剂量组、QYHJ幼龄组减小最为显著(P<0.05);CMI和RVMI则无明显变化。QYHJ幼龄组KMI减小(P<0.05,P<0.01),其他药物干预组无显著变化。结论:QYHJ在降压的...
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| 关 键 词： | 潜阳合剂 自发性高血压 大鼠 心脏质量指数 肾脏质量指数 血压 |
Effect of QYHJ Intervention in Spontaneously Hypertensive Rats (SHR) and Heart and Renal Function and Quality Index. |
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| Liu Chun,Jiang Mei-xian. Effect of QYHJ Intervention in Spontaneously Hypertensive Rats (SHR) and Heart and Renal Function and Quality Index.[J]. Journal of Henan University of Chinese Medicine, 2011, 26(1) |
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| Authors: | Liu Chun Jiang Mei-xian |
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| Affiliation: | Liu Chun1,2,Jiang Mei-xian2 NO.3 Affiliated Hospital of Henan College of Chinese Medicine,Zhengzhou,Henan,China 450008 Affiliated Hospital of Shanghai University of TCM,Shanghai shuguang,Shanghai,China 201203 |
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| Abstract: | Objective: To observe the effect of QYHJ intervention in spontaneously hypertensive rats(SHR) and heart and renal function and quality index.Methods: 77 day-old SHR males were randomly divided into 5 groups: high,medium and low doses of QYHJ groups,XinPuLi group and SHR control group.14 d after and before using drugs,mouse tail pressure measurement method for measuring the pressure and the average of three times were taken.when 140 day-old rats were executed,measuring the quality of whole heart and left and... |
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| Keywords: | Qianyang He Ji(QYHJ) spontaneously hypertensive rats heart quality index renal quality index pressure |
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