| 豆腐果素缓释微丸的研究.Ⅱ.在大鼠胃肠道的吸收 |
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| 引用本文： | 卢文芸,陆伟根,陈亭亭,李军. 豆腐果素缓释微丸的研究.Ⅱ.在大鼠胃肠道的吸收[J]. 中国医药工业杂志, 2007, 38(3): 241-244 |
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| 作者姓名： | 卢文芸 陆伟根 陈亭亭 李军 |
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| 作者单位： | 上海医药工业研究院,上海,200437 |
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| 摘 要： | 采用在体灌流法考察了豆腐果素在大鼠胃肠道的吸收情况。根据该结果研制可持续释药12h的缓释微丸。试验结果表明，豆腐果素在大鼠胃、小肠各段均有吸收，在结肠处无吸收。豆腐果素缓释微丸与普通片剂相比，缓释微丸在狗体内的平均滞留时间（MRT）明显延长。
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| 关 键 词： | 豆腐果素 在体吸收 缓释微丸 药动学 |
| 文章编号： | 1001-8255（2007）03-0241-04 |
| 修稿时间： | 2006-12-19 |
Studies on Sustained-release Helicidum Pellets.Ⅱ.Absorption in Rat Gastrointestinal Tract |
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| LU Wen-yun,LU Wei-gen,CHEN Ting-ting,LI Jun. Studies on Sustained-release Helicidum Pellets.Ⅱ.Absorption in Rat Gastrointestinal Tract[J]. , 2007, 38(3): 241-244 |
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| Authors: | LU Wen-yun LU Wei-gen CHEN Ting-ting LI Jun |
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| Affiliation: | Shanghai Institute of Pharmaceutical Industry, Shanghai 200437 |
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| Abstract: | The absorption characteristics of helicidum were investigated by using the in situ perfusion method in rat gastrointestinal tract. According to this study, sustained-release helicidum pellets for 12h were developed. The results showed that helicidum could be absorbed in stomach, duodenum, jejunum and ileum, but not in colon. Compared with conventional tablets, the MRT of sustained-release helicidum pellets in beagle dogs were prolonged significantly. |
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| Keywords: | helicidum in situ absorption sustained-release pellets pharmacokinetics |
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