脑动脉支架置入术后血清炎性标志物与缺血性脑血管事件的关系

目的 探讨血清炎性标志物与脑动脉（颈动脉或椎-基底动脉）支架置入术后围手术期缺血性脑血管事件的关系。方法测定44例颈动脉或椎-基底动脉支架置入患者术后1d的外周血中血清高敏C反应蛋白、基质金属蛋白酶-9及可溶性CD40配体的水平，同时观察围手术期缺血性脑血管事件的发生情况。结果共有4例出现围手术期缺血性脑血管事件。血清基质金属蛋白酶-9在围手术期出现缺血性脑血管事件者中高于未出现者（1291．16±549．29ng／mlvs701．45±497．30ng/ml，P=0．030），血清高敏C反应蛋白与可溶性CD40配体在二者之间的差异无统计学意义。结论脑动脉支架置入术后的高基质金属蛋白酶-9水平可能与围手术期缺血性脑血管事件危险增加有一定的相关性。

Association Between Serum Inflammatory Markers and Ischemic Cerebrovascular Events in Patients after Brain Artery Stenting

Objective To assess the association between levels of serum inflammatory markers and periproeedural isehemie eerebrovascular events（PICE） in patients undergoing brain artery （carotid or verte-brobasilar artery） stenting. Methods Serum high sensitivity C-reactive protein （hsCRP）, soluble CD 40 ligand （sCD 40L）and matrix metalloproteinase-9 （MMP-9）were assayed in peripheral blood samples obtained 1 d after stenting in 44 patients undergoing carotid or vertebrobasilar artery stenting, and the occurrence of PICE were observed as well. Results PICE presented in 4 cases. Levels of serum MMP-9 were higher in patients with PICE than in those without（ 1291.16 ±549.29 ng/ml vs 701.45 ±497.30 ng/ml,P =0. 030）. No differences were found for hsCRP and sCD 40L between patients with and without PICE. Conclusion High levels of serum MMP-9 ld after stenting may correlate with an increased risk of PICE in patients under-going brain artery stenting.