| 复方黄芩提取物对小鼠体内流感病毒mRNA复制和干扰素(IFN)表达的影响 |
| |
| 引用本文： | 初明,初正云,王丹丹.复方黄芩提取物对小鼠体内流感病毒mRNA复制和干扰素(IFN)表达的影响[J].中药材,2007,30(1):63-65. |
| |
| 作者姓名： | 初明 初正云 王丹丹 |
| |
| 作者单位： | 1. 北京大学医学部基础医学院,北京,100083
2. 辽宁中医药大学药学院,辽宁沈阳,110032 |
| |
| 摘 要： | 目的:研究复方黄芩提取物对小鼠体内流感病毒(influenza virus,Ⅳ)mRNA复制的抑制作用和干扰素(interferon,IFN)表达的诱生作用。方法:以流感病毒鼠肺适应株A/FM/1/47(H1N1)感染的小鼠肺炎为模型,采用RT-PCR技术测定小鼠体内流感病毒mRNA和干扰素含量。观察复方黄芩提取物对小鼠体内流感病毒mRNA复制和IFN表达的影响。结果:复方黄芩提取物对小鼠体内流感病毒mRNA表达有较好的抑制作用(P<0.01),对干扰素的表达有诱生作用(P>0.05)。结论:复方黄芩提取物具有诱生干扰素、抑制流感病毒在小鼠体内的复制作用。
|
| 关 键 词： | 复方黄芩提取物 流感病毒 干扰素 |
| 文章编号： | 1001-4454(2007)01-0063-03 |
| 修稿时间： | 2006-05-17 |
The Extract of Compound Radix Scutellariae on mRNA Replication and IFN Expression of Influenza Virus in Mice |
| |
| CHU Ming,CHU Zheng-yun,WANG Dan-dan.The Extract of Compound Radix Scutellariae on mRNA Replication and IFN Expression of Influenza Virus in Mice[J].Jorunal of Chinese Medicinal Materials,2007,30(1):63-65. |
| |
| Authors: | CHU Ming CHU Zheng-yun WANG Dan-dan |
| |
| Institution: | 1. Department of Immunology, School of Basic Medicine, Peking University, Beijing 100083, China; 2. Pharmacy department Liaoning University of Traditional Chinese Medicine , Shenyang 110032, China |
| |
| Abstract: | OBJECTIVE: To study the extract of compound Radix Scutellariae on inhibiting the mRNA replication and inducing the INF expression of influenza virus in mice's vivo. METHODS: Influenza virus infected mice pneumono-adaption stock A/FM/1/47 (H1N1) evoked mice pneumonia taken as animal model. RT-PCR was adopted to measure the content of influenza virus's mRNA and INF in mice to study the effect of the extract on mRNA replication and IFN expression. RESULTS: The extract of compound Radix Scutellariae could inhibit influenza virus' s mRNA replication (P < 0.01) and induce interferon expression in mice (P > 0.05). CONCLUSION: The extract of compound Radix Scutellariae can induce interferon and inhibit influenza virus replication in mice. |
| |
| Keywords: | mRNA |
| 本文献已被 CNKI 维普 万方数据 等数据库收录！ |
