锑剂和砷剂合并应用的毒性研究

酒石酸锑钾和葡萄糖酸锑钠均含有微量砷,各国对此二种锑剂中砷量限度的规定并不相同。本文对于微量砷影响锑剂毒性的问题,用小白鼠进行了比较系统的研究。结果表明当砷含量在200ppm以下时对二种锑剂的毒性无明显影响,仅当砷含量增至2000—20000ppm时二种锑剂的毒性始相应增加。同时按Loewe图解分析法用小白鼠分析酒石酸锑钾(PAT_sbⅢ)与三氧化二砷(AS^Ⅲ)和葡萄糖酸锑钠(SAG_sbv)与砷酸氢二钠(AS^v)合用时的毒性,证明PAT_sbⅢ与AS^Ⅲ间,SAG_sbv与AS^v 间的毒性均呈相加作用。

STUDIES ON THE COMBINED TOXICITIES OF ANTIMONIALS AND ARSENICALS

Both tartar emetic and sodium antimony gluconate contain minute amounts of arsenic. The permissible limits of the arsenic content of the 2 drugs differ in different pharmacopoeias. In order to find the safety limit of arsenic, a systematic study on the effects of minute amounts of arsenic on the toxicity of antimonials was undertaken in mice. The results indicate that if the arsenic contents were below 200 ppm, no significant influence on the toxicity of the 2 antimonials was found. The toxicity of the 2 antimonials began to increase only when the arsenic content was increased to 2000—20000 ppm. By analyzing the toxicity of the combined use of tartar emetic (PAT_sb^Ⅲ) with arsenic trioxide (AS^Ⅲ), and sodium antimony gluconate (SAG_sb^v) with disodium hydrogen arsenate (AS^v) in mice, according to the method of Loewe, we found that there was an additional effect in their toxicities.