GM1在流体冲击致大鼠脑损伤后的保护作用观察

评价单唾液酸西己糖神经糖甙脂钠盐（ｍＯＮＯＳＩＡＬＯＴＥＲＡＨＥＸＯＳＹＬＧＡＮＧＬＩＯＳＩＤＥ，ｇｍ１）在流体冲击致大鼠脑损伤（Ｆｌｕｉｄ－ｐｅｒｃｕｓｓｉｏｎ ｂｒａｉｎ ｉｎｊｕｒｙ，ＦＢＰＩ）后急性期对大脑的保护作用，以期为脑损伤的临床治疗提供实验依据。方法流体冲击致大鼠闭合型脑损伤后，用干湿法测定脑组织水含量、氢清除法观测局部脑血流量的改变，以及病理改变。结果大鼠脑损伤后ＧＭ１能显著降低

Protective effect of monosialotetrahexosylganglioside on fluid-percussion brain injury in rats

Objective To evaluate the protective effect of monosialotetrahexosylganglioside (GM1) on the acute stage of fluid percussion brain injury (FPBI) in rats to provide experimental basis for the clinical treatment. Methods After the establishment of rat model of FPBI, the water content of brain tissues was detected with dry wet method and regional cerebral blood flow (rCBF) was measured with H 2 elimination method. Pathological changes of the brain were observed with light microscope. Results GM1 significantly inhibited the elevation of the water content in the brain and showed no effect on the rCBF after FPBI. Meanwhile, GM1 significantly ameliorated the pathological manifestation of the brains. Conclusion Early administration of GM1 can prevent ischemia/reperfusion damages of rCBF, improve cerebral blood supply and reduce cerebral edema, denaturation and necrosis of the neurons after fluid percussion brain injury in rats.