替米沙坦对部分中老年高血压病胰岛素抵抗及糖、脂代谢的影响

目的 观察替米沙坦对部分中老年高血压病胰岛素抵抗及糖、脂代谢的影响.方法 选择中老年高血压病80例(年龄≥60岁),口服替米沙坦治疗8周.治疗前、后观察患者的体重指数(BMI)、收缩压(SBP)、舒张压(DBP)、空腹血糖(FPG)、餐后2小时血糖(2hPG)、三酰甘油(TG)、总胆固醇(TC)、高密度脂蛋白胆固醇(HDL-C)、低密度脂蛋白胆固醇(LDL-C)、空腹胰岛素(FINS)、胰岛素抵抗指数(HOMA-IR).结果 替米沙坦治疗后,患者的BMI、SBP、DBP、FPG、2hPG、TG、TC、LDL-C、FINS、HOMA-IR均显著下降(P＜0.05),HDL-C显著提高(P＜0.05).结论 替米沙坦除了有较好的降压效果,还可以改善中老年高血压病患者胰岛素抵抗及糖、脂代谢异常,从而预防心脑血管疾病的发生.

Effect of telmisartan on insulin resistance and glucose and lipid metabolism in the middle-aged and elderly patients with hypertension

Objective To observe the effect of telmisartan on insulin resistance and glucose and lipid metabolism in the middle-aged and elderly patients with hypertension.Methods The middle-aged and elderly patients with hypertension（over 60 years old,n=80）were selected and given telmisartan for 8 weeks.Their body mass index（BMI）,systolic blood pressure（SBP）,diastolic blood pressure（DBP）,fasting plasma glucose（FPG）,2 hours postprandial glucose（2hPG）,triglycerides（TG）,total cholesterol（TC）,high-density lipoprotein cholesterol（HDL-C）,low-density lipoprotein cholesterol（LDL-C）,fasting insulin（FINS）,and homeostasis model assessment of insulin resistance（HOMA-IR）were observed before and after treatment.Results The patients,BMI,SBP,DBP,FPG,2hPG,TG,TC,LDL-C,FINS,HOMA-IR were decreased significantly after treatment（P〈0.05）,while the level of high-density lipoprotein cholesterol（HDL-C）were increased significantly（P〈0.05）.Conclusion Besides the better antihypertensive effect,telmisartan can improved insulin resistance and glucose and lipid metabolism,in order to prevent cardiovascular and cerebrovascular diseases.