Recovery of memory in chicks after disruption during learning: The reversibility of amnesia induced by protein synthesis inhibitors |
| |
Authors: | K A Radyushkin K V Anokhin |
| |
Institution: | (1) P. K. Anokhin Science Research Institute of Normal Physiology, Russian Academy of Medical Sciences, 6B Nikitin Street, 103009 Moscow, Russia |
| |
Abstract: | Protein synthesis inhibitors given during learning are known to disrupt memory in various animal species in several models
of learning. However, there are suggestions that amnesia induced by protein synthesis inhibitors is not permanent-memory can
be recovered by a reminder procedure, i.e., by presenting the animal with one of the components of the external environment
which was part of the learning situation. The aim of the present work was to determine the existence of the reminder phenomenon
in a well-studied model of single-session training to passive avoidance in chicks. Cycloheximide and anisomycin were used
to induce amnesia. Reminder was performed using the aversive taste of methylanthranilate 24 h afte training, and testing was
conducted 48 h after training. The results obtained provide evidence that memory disrupted by protein synthesis inhibitors
in chicks can be recovered by the reminder procedure.
Translated from Rossiiskii Fiziologicheskii Zhurnal imeni I. M. Sechenova, Vol. 83, No. 11-12, pp. 11–18, November–December,
1997. |
| |
Keywords: | Memory learning amnesia reminder |
本文献已被 PubMed SpringerLink 等数据库收录! |
|