The sleep phenotype of Borderline Personality Disorder: A systematic review and meta-analysis |
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| Affiliation: | 1. NHC Key Laboratory of Mental Health (Peking University), National Clinical Research Center for Mental Disorders (Peking University Sixth Hospital), Peking University Sixth Hospital, Peking University Institute of Mental Health, 51 Huayuanbei Road, Beijing 100191, China;2. Faculty of Medicine, Department of Psychiatry, Chinese University of Hong Kong, Sha Tin, Hong Kong SAR, China;3. National Institute on Drug Dependence and Beijing Key Laboratory on Drug Dependence Research, Peking University, 38 Xueyuan Road, Beijing 100191, China;4. Department of Psychiatry, Renmin Hospital of Wuhan University, Wuhan, China;5. Department of Neurology, Tongji Hospital of Tongji Medical College of Huazhong University of Science and Technology, Wuhan, China;6. Department of Pediatrics, Zhongnan Hospital of Wuhan University, Wuhan, China;7. Affiliated Wuchang Hospital, Wuhan University of Science and Technology, Wuhan, China;8. Department of Neurology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China;9. Wuhan Children''s Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China;10. Department of Psychiatry, Affiliated Wuhan Mental Health Center, Tongji Medical College of Huazhong University of Science and Technology, Wuhan, China;11. Department of Social Work and Social Administration, University of Hong Kong, Hong Kong, China;1. Centre for Developmental Psychiatry and Psychology, Department of Psychiatry, School of Clinical Sciences at Monash Health, Monash University, Building 1, 270 Ferntree Gully Road, Notting Hill, VIC 3168, Australia;2. Early in Life Mental Health Service, Monash Medical Centre, 246 Clayton Road, Clayton, VIC 3168, Australia;3. Centre for Women''s Mental Health, The Royal Women''s Hospital, 20 Flemington Road, Parkville, VIC 3052, Australia;1. Neurobiology of Stress Research Group, Szentágothai János Research Centre, University of Pécs, Pécs, Hungary;2. Institute of Bioanalysis, University of Pécs, Medical School, Pécs, Hungary;3. Institute for Translational Medicine and 1st Department of Medicine, University of Pécs, Medical School, Pécs, Hungary;4. Momentum Translational Gastroenterology Research Group, Hungarian Academy of Sciences University of Szeged, Szeged, Hungary;5. Department of Laboratory Medicine, University of Pécs, Medical School, Pécs, Hungary;6. Department of Cardiology, 1st Department of Medicine, University of Pécs, Medical School, Pécs, Hungary;7. Department of Haematology, 1st Department of Medicine, University of Pécs, Medical School, Pécs, Hungary;8. Department of Gastroenterology, 1st Department of Medicine, University of Pécs, Medical School, Pécs, Hungary;9. Institute for Translational Medicine, University of Pécs, Medical School, Pécs, Hungary;10. Department of Pathophysiology, University of Szeged, Medical School, Szeged, Hungary;11. Institute of Surgical Research, University of Szeged, Hungary;12. 1st Department of Paediatrics, Semmelweis University, Budapest, Hungary;13. Department of Psychiatry and Psychotherapy, University of Pécs, Medical School, Pécs, Hungary |
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| Abstract: | AimTo delineate the sleep profile of Borderline Personality Disorder (BPD).MethodA meta-analysis to synthesise findings on the objective and subjective sleep characteristics of BPD.ResultsWe identified 32 studies published between 1980 and December 2015. Meta-analysis indicated significant differences between BPD and healthy control groups across objective sleep continuity (sleep onset latency, total sleep time, sleep efficiency) and architecture (rapid eye movement latency/density, slow wave sleep) measures, and self-reported sleep problems (nightmares, sleep quality). Findings were independent of depression (in clinical and community populations), and concomitant psychotropic medication use. There were few significant differences between BPD and clinical (majority depressed) control groups.ConclusionBPD is associated with comparable sleep disturbances to those observed in depression. These disturbances are not solely attributable to comorbid depression. Given growing evidence that sleep disturbance may exacerbate emotional dysregulation and suicide risk, treatments for BPD should explicitly address sleep problems. Future studies should utilise prospective designs to ascertain whether (and in which circumstances) sleep problems predate or follow the onset of the disorder. |
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| Keywords: | BPD Sleep Polysomnography Meta-analysis Systematic review |
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