Extracellular matrix proteins in healthy and retained placentas,comparing hemochorial and synepitheliochorial placentas |
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| Affiliation: | 1. Department of Biochemistry, Faculty of Veterinary Medicine, University of Life Science in Lublin, 20-033 Lublin, Akademicka 12, Poland;2. Clinic for Obstetrics and Pathology of Pregnancy, Medical University, 20-081 Lublin, Staszica 16, Poland;3. Ist Clinic for Gynecological Oncology and Gynecology, Medical University, 20-081 Lublin, Staszica 16, Poland;4. Unit for Gynecology and Obstetrics with Pathology of Pregnancy, City Hospital in Swidnik, Al. Lotników Polskich 18, 21-040 Świdnik, Poland;1. Department of Epidemiology, School of Public Health, University of Washington, Seattle, WA, United States;2. Center for Perinatal Studies, Swedish Medical Center, Seattle, WA, United States;3. Department of Epidemiology, Harvard T.H. Chan School of Public Health, Boston, MA, United States;1. Embryo Implantation Laboratory, Hudson Institute, Clayton, VIC, Australia;2. Department of Molecular and Translational Medicine, Monash University, Clayton, VIC, Australia;3. Department of Anatomy and Developmental Biology, Monash University, Clayton, VIC, Australia;1. Department of Molecular Medicine and Anatomy, Nippon Medical School, Tokyo 113-8602, Japan;2. Department of Obstetrics and Gynecology, Jichi Medical University, Tochigi 329-0498, Japan;3. Department of Obstetrics and Gynecology, Faculty of Medicine, University of Toyama, Toyama 930-0194, Japan;1. Obstetrical Department, No.215 Hospital of Shanxi Nuclear Industry, Xianyang, Shaanxi, 712000, China;2. Obstetrical Department, Yan''an University Affiliated Hospital, Yan''an, Shaanxi, 716000, China;3. The 2nd Department of Obstetrical, Northwest Women and Children''s Hospital, Xian, Shaanxi, 710000, China;4. Obstetrical Department, Northwest Women and Children''s Hospital, Xian, Shaanxi, 710000, China;5. Gynaecology and Obstetrics, 4th (Xing Yuan) Hospital of Yulin, Yulin, Shaanxi, 719000, China;6. Gynaecology and Obstetrics, Xian NO.1 Hospital, Xian, Shaanxi, 710000, China;7. Obstetrical Department, Shaanxi Baoji Maternal and Child Health Hospital, Baoji 721000, China;8. Obstetrical Department, Yan''an People''s Hospital, Yanan, Shaanxi, 716000, China;1. Department of Obstetrics and Gynecology, Meir Medical Center, Kfar Saba, Israel;2. Sackler School of Medicine, Tel Aviv University, Israel |
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| Abstract: | The placenta expresses structural and biologically active proteins. Their synthesis is mainly regulated by genomic or nongenomic signals and modulated by hormones. These protein profiles are altered during different stages of pregnancy. The biological properties of extracellular matrix (ECM) proteins were defined and described in a number of tissues including placenta. These properties enable them to be the main players in the processes of attachment or invasion into the endometrium during initial placenta formation and its timely separation after delivery and detachment. In this review, we focused on the role of ECM proteins during attachment of the placenta to the uterine wall, its timely separation, and the implications of this process on retained or pathologically attached placenta.Although the amount of published information in this area is relatively scant, some of the key proteins and processes are well defined. We focused on the available data detailing the ECM protein profiles of human (histologically thin; hemochorial) and bovine (histologically thick; epitheliochorial) placentas and compared the shared and unique ECM proteins that are relevant to placental attachment and separation. |
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| Keywords: | Protein profile Hemochorial placenta Synepitheliochorial placenta Attachment Retained placenta |
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