Increased trophoblast inclusions in placentas from prematurely born infants: A potential marker of risk for preterm neurodevelopmental outcomes |
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| Affiliation: | 1. Department of Psychology, Columbia University, New York, NY, USA;2. Department of Pathology & Cell Biology, Columbia University Medical Center, New York, NY, 10032, USA;3. Department of Pediatrics, Columbia University Medical Center, New York, NY, 10032, USA;4. Department of Psychiatry, Columbia University Medical Center, New York, NY, 10032, USA;1. Dept. of Biology and Electron Microscopy Center, Trinity College, Hartford, CT, USA;2. Dept. of Life Sciences, University of Siena, Via A. Moro, 53100 Siena, Italy;1. Placental Analytics, LLC, Larchmont, NY, USA;2. Institute for Basic Research, Staten Island, NY, USA;3. Obstetrics and Gynecology, NewYork Methodist Hospital, Brooklyn, NY, USA;1. Department of Pathology, Women and Infants Hospital, Providence, RI, 02905, United States;2. Department of Pathology and Laboratory Medicine, Alpert Medical School of Brown University, Providence, RI, 02905, United States |
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| Abstract: | Trophoblast inclusions (TIs) are placental abnormalities of the trophoblast bilayer. Present in 2–8% of full-term placentas, they are associated with poor neurodevelopment, including autism. Although previously unstudied, examination of chorionic villi from 108 preterm births revealed a ∼4 fold increase in the frequency of TIs (30.5%). Frequency of TIs was inversely related to gestational age (GA); 43% of placentas <30 weeks and 20% of placentas ≥32 weeks had TIs (χ2 = 4.41, p = 0.036). This increased prevalence in preterm infants suggests that TIs may indicate adverse intrauterine processes or undetected genetic abnormalities and could identify infants at risk for poor neurodevelopment. |
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| Keywords: | Preterm birth Trophoblast inclusions Placenta Chorioamnionitis Neurodevelopmental risk TI" },{" #name" :" keyword" ," $" :{" id" :" kwrd0040" }," $$" :[{" #name" :" text" ," _" :" trophoblast inclusion GA" },{" #name" :" keyword" ," $" :{" id" :" kwrd0050" }," $$" :[{" #name" :" text" ," _" :" gestational age |
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