Review: Placental adaptations to the presence of maternal asthma during pregnancy |
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| Affiliation: | 1. UQ Centre for Clinical Research, The University of Queensland, Herston, Queensland 4029, Australia;2. School of Chemistry and Molecular Biosciences, The University of Queensland, Brisbane, Queensland 4072, Australia;3. Grantley Stable Neonatal Unit, Royal Brisbane and Women''s Hospital, Herston, Queensland 4029, Australia;1. Christopher Chen Oocyte Biology Research Laboratory, University of Queensland Centre for Clinical Research, Australia;2. Exosome Biology Laboratory, Centre for Clinical Diagnostics, University of Queensland Centre for Clinical Research, Royal Brisbane and Women''s Hospital, The University of Queensland, Brisbane QLD 4029, Australia;3. Maternal-Fetal Medicine, Department of Obstetrics and Gynecology, Ochsner Clinic Foundation, New Orleans, USA;1. Division of Pulmonary, Critical Care and Sleep Medicine, Icahn School of Medicine at Mount Sinai, New York, NY;3. Department of Preventive Medicine, Icahn School of Medicine at Mount Sinai, New York, NY;6. Mindich Child Health & Development Institute, Icahn School of Medicine at Mount Sinai, New York, NY;2. Department of Pediatrics, Kravis Children''s Hospital, Icahn School of Medicine at Mount Sinai, New York, NY;4. Department of Biostatistics, Harvard School of Public Health, Boston, Mass;5. Department of Environmental Health, Harvard School of Public Health, Boston, Mass;1. Biocomputing Laboratory, Computer and Information Technology Engineering Department, Amirkabir University of Technology, Tehran, Iran;2. Department of Immunology, School of Public Health, Tehran University of Medical Sciences, Tehran, Iran;3. Neurophysiology Research Center, Department of Physiology, Shahid Beheshti University of Medical Sciences, Tehran, Iran |
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| Abstract: | Asthma is a highly prevalent chronic medical condition affecting an estimated 12% of pregnant, women each year, with prevalence of asthma greatest (up to 16%) among the socially disadvantaged. Maternal asthma is associated with significant perinatal morbidity and mortality including preterm births, neonatal hospitalisations and low birthweight outcomes each year. We have identified that the placenta adapts to the presence of chronic, maternal asthma during pregnancy in a sex specific manner that may confer sex differences in fetal outcome. The male fetus was at greater risk of a poor outcome than a female fetus in the presence of maternal asthma and an acute inflammatory event such as an asthma exacerbation. This review will examine the role of sex specific differences in placental function on fetal growth and survival. |
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| Keywords: | Placenta Asthma Fetus Sex Growth |
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