Chronic hyperosmotic stress inhibits renal Toll-Like Receptors expression in striped catfish (Pangasianodon hypophthalmus,Sauvage) exposed or not to bacterial infection |
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| Affiliation: | 1. College of Marine Sciences, Hainan University, Haikou, Hainan, 570228, PR China;2. School of Fisheries, Aquaculture and Aquatic Sciences, Auburn University, Auburn, AL, 36849, USA;3. Department of Aquatic Animal Medicine and Management, Faculty of Veterinary Medicine, Assiut University, Assiut, 71526, Egypt;4. Center of Excellence for Shrimp Molecular Biology and Biotechnology (CENTEX Shrimp), Faculty of Science, Mahidol University, Bangkok, 10400, Thailand;5. National Center for Genetic Engineering and Biotechnology (BIOTEC), National Science and Technology Development Agency (NSTDA), Pathum Thani, 12120, Thailand;6. USDA, Agricultural Research Service, Harry K. Dupree Stuttgart National Aquaculture Research Center, 2955 Highway 130 East, Stuttgart, AR, 72160, USA;1. Central Laboratory of Yongchuan Hospital, Chongqing Medical University, Chongqing, 402160, China;2. Key Laboratory of Laboratory Medical Diagnostics, Ministry of Education, Department of Laboratory Medicine, Chongqing Medical University, Chongqing, 400016, China;1. Section of Immunology, Norwegian Veterinary Institute, Oslo, Norway;2. Department of Food Safety and Infection Biology, Norwegian University of Life Sciences, Oslo, Norway;3. Nofima AS, Norwegian Institutes of Food, Fisheries & Aquaculture Research, Ås, Norway;1. Fundação Instituto de Pesca do Estado do Rio de Janeiro, 28625-020 Nova Friburgo, RJ, Brazil;2. Laboratório de Aquacultura, Escola de Veterinária, Universidade Federal de Minas Gerais, 31270-901 Belo Horizonte, MG, Brazil;3. Programa de Pós-Graduação em Zoologia de Vertebrados da PUC Minas, 500, prédio 41, Belo Horizonte, MG 30525-610, Brazil |
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| Abstract: | Toll-like Receptors (TLRs) are the first innate receptors in recognizing pathogen-associated molecular patterns. In fish, upregulation of toll-like receptors during infection has been largely demonstrated while the effects of abiotic stressors on their expression remain poorly investigated. In this study, striped catfish were submitted during 20 days to three salinity profiles (freshwater, low saline water, saline water), followed by injection of a bacterial strain of Edwardsiella ictaluri. The expression of TLRs 1, 3, 4, 5, 7, 9, 19, 21, and 22 was measured in kidney at different time points in non infected and infected striped catfish. Infection induced overexpression of TLRs 1, 3, 4, 5, 7, 21 and 22. With elevated salinity, the expression of all TLRs, except TLR5, was severely decreased, particularly after bacterial infection. The TLRs responsiveness of striped catfish facing bacterial disease and salinity stress and possible consequences on striped catfish immune response's efficiency are discussed. |
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| Keywords: | Toll-like Receptors Salinity Infection Striped catfish PAMP" },{" #name" :" keyword" ," $" :{" id" :" kwrd0035" }," $$" :[{" #name" :" text" ," _" :" Pathogen-Associated Molecular Pattern TLR" },{" #name" :" keyword" ," $" :{" id" :" kwrd0045" }," $$" :[{" #name" :" text" ," _" :" Toll-Like Receptor MAPK" },{" #name" :" keyword" ," $" :{" id" :" kwrd0055" }," $$" :[{" #name" :" text" ," _" :" Mitogen-Activated Protein Kinase |
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