The correlation between central and peripheral oxytocin concentrations: A systematic review and meta-analysis |
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| Institution: | 1. NORMENT, KG Jebsen Centre for Psychosis Research, Division of Mental Health and Addiction, University of Oslo, Oslo University Hospital, Oslo, Norway;2. Department of Psychology, University of Oslo, Oslo, Norway;3. Telethon Kids Institute, University of Western Australia, Australia;4. Cooperative Research Centre for Living with Autism (Autism CRC), Long Pocket, Brisbane, Australia;1. Macquarie University, NSW, Australia;2. University of Sydney, NSW, Australia;1. Department of Psychiatry, University of Bonn, Bonn, Germany;2. Division of Medical Psychology, University of Bonn, Bonn, Germany;3. German Center for Neurodegenerative Diseases, Bonn, Germany;4. Department of Psychology, Laboratory for Biological and Personality Psychology, University of Freiburg, Freiburg, Germany;5. Freiburg Brain Imaging Center, University Medical Center, University of Freiburg, Freiburg, Germany;1. King’s College London, Institute of Psychiatry, Psychology, and Neuroscience, Department of Psychological Medicine, London, United Kingdom;2. Singapore General Hospital,20 College Road, Academia, 169865, Singapore;3. Department of Psychology, Illia State University, Tbilisi, Georgia;1. Department of Psychology, University of Haifa, Haifa, Israel;2. School of Psychology, University of Birmingham, Birmingham, Unnited Kingdom |
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| Abstract: | There is growing interest in the role of the oxytocin system in social cognition and behavior. Peripheral oxytocin concentrations are regularly used to approximate central concentrations in psychiatric research, however, the validity of this approach is unclear. Here we conducted a pre-registered systematic search and meta-analysis of correlations between central and peripheral oxytocin concentrations. A search of databases yielded 17 eligible studies, resulting in a total sample size of 516 participants and subjects. Overall, a positive association between central and peripheral oxytocin concentrations was revealed r = 0.29, 95% CI (0.14, 0.42), p < 0.0001]. This association was moderated by experimental context Qb(4), p = 0.003]. While no association was observed under basal conditions (r = 0.08, p = 0.31), significant associations were observed after intranasal oxytocin administration (r = 0.66, p < 0.0001), and after experimentally induced stress (r = 0.49, p = 0.001). These results indicate a coordination of central and peripheral oxytocin release after stress and after intranasal administration. Although popular, the approach of using peripheral oxytocin levels to approximate central levels under basal conditions is not supported by the present results. |
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| Keywords: | Oxytocin Meta-analysis Blood plasma Central concentrations |
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