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Differentiation of amniotic epithelial cells into various liver cell types and potential therapeutic applications |
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| Institution: | 1. University of Cagliari, Department of Biomedical Sciences, Unit of Experimental Medicine, Cagliari, Italy;2. Karolinska Institutet, Department of Laboratory Medicine, Division of Pathology, Stockholm, Sweden;1. School of Chinese Medicine, The University of Hong Kong, 10 Sassoon Road, Pokfulam, Hong Kong, China;2. School of Traditional Chinese Medicine, Southern Medical University, Guangzhou, Guangdong, China;3. Research Centre of Heart, Brain, Hormone & Healthy Aging, the University of Hong Kong, Hong Kong, China;4. Morningside Laboratory for Chemical Biology and Department of Chemistry, The University of Hong Kong, Pokfulam Road, Hong Kong, China;5. Institute of Clinical Pharmacology, Guangzhou University of Chinese Medicine, Guangzhou, Guangdong, China;1. Division of Nephrology, Huashan Hospital, Fudan University, Shanghai 200040, China;2. Department of General Surgery, Huashan Hospital, Fudan University, Shanghai 200040, China;3. Department of Biochemistry, College of Basic Medicine, Shanghai University of Traditional Chinese Medicine, Shanghai 201203, China;4. Department of Pathology, Yale University School of Medicine, New Haven 06520, USA;5. Shanghai Tenth People’s Hospital, Medical School, Tongji University, Shanghai 200072, China;6. Division of Nephrology, Dezhou People’s Hospital, Shandong 253014, China;7. Laboratoire PROTEE, Bâtiment R, Université du Sud Toulon-Var, 83957 LA GARDE Cedex, France;8. Institute of Biochemistry and Cell Biology, Shanghai Institute for Biological Sciences, Chinese Academy of Sciences, Shanghai 200031, China;1. Department of Physiology, The University of Melbourne, Parkville, VIC 3010, Australia;2. School of Biomedical Sciences, The University of Queensland, St. Lucia, QLD 4072, Australia;3. School of Medical Science, Menzies Health Institute Queensland, Griffith University, Southport, QLD, 4222, Australia;1. Key Laboratory of Combined Multi-organ Transplantation, Ministry of Public Health, Department of Hepatobiliary and Pancreatic Surgery, First Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou, China;2. Collaborative Innovation Center for Diagnosis and Treatment of Infectious Diseases, Hangzhou, China;3. Ningbo First Hospital (Ningbo Hospital of Zhejiang University), Ningbo, China;1. Centre for Inflammatory Diseases, Monash University, Melbourne, Australia;2. Centre for Genetic Diseases, Monash Institute of Medical Research, Monash University, Melbourne, Australia;3. Department of Obstetrics & Gynaecology, University of Melbourne & Pregnancy Research Centre, Department of Perinatal Medicine, Royal Women''s Hospital, Melbourne, Australia;4. Gastroenterology and Hepatology Unit, Monash Health, Melbourne, Australia;5. Department of Anatomy and Developmental Biology, Monash University, Melbourne, Australia;1. Department of Cytophysiology, Chair of Histology and Embryology, School of Medicine in Katowice, Medical University of Silesia, Medyków 18, 40-758 Katowice, Poland;2. Students Scientific Society, School of Medicine in Katowice, Medical University of Silesia, Medyków 18, 40-758 Katowice, Poland |
| Abstract: | The aim of Regenerative Medicine is to replace or regenerate human cells, tissues or organs in order to restore normal function. Among all organs, the liver is endowed with remarkable regenerative capacity. Nonetheless, there are conditions in which this ability is impaired, and the use of isolated cells, including stem cells, is being considered as a possible therapeutic tool for the management of chronic hepatic disease.Placenta holds great promise for the field of regenerative medicine. It has long been used for the treatment of skin lesions and in ophthalmology, due to its ability to modulate inflammation and promote healing. More recently, cells isolated from the amniotic membrane are being considered as a possible resource for tissue regeneration, including in the context liver disease. Two cell types can be easily isolated from human amnion: epithelial cells (hAEC) and mesenchymal stromal cells (hAMSC). However only the first cell population has been demonstrated to be a possible source of proficient hepatic cells. This review will summarize current knowledge on the differentiation of hAEC into liver cells and their potential therapeutic application. |
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