The origin and evolution of Basigin(BSG) gene: A comparative genomic and phylogenetic analysis |
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| Institution: | 1. Department of Gastroenterology, Shanghai East Hospital, Tongji University School of Medicine, Shanghai 200120, China;2. Department of Gastroenterology, Shanghai Tongji Hospital, Tongji University School of Medicine, Shanghai 200062, China;3. Organ Transplant Center, Xiangya 3rd Hospital of Central South University, Changsha, Hunan 410013, China;4. Marine Biotechnology Research Center, Shandong Provincial Key Laboratory of Animal Cells and Developmental Biology, Institute of Developmental Biology, School of Life Sciences, Shandong University, Jinan, Shandong 250100, China;1. Institute of Molecular Biology and Biotechnology, FORTH, Heraklion, Greece;2. Department of Biochemistry and Molecular Biology, Bio21 Molecular Science and Biotechnology Institute, The University of Melbourne, Melbourne, 3051 VIC, Australia;3. Biological Optical Microscopy Platform, The University of Melbourne, Melbourne, 3051 VIC, Australia;4. School of BioSciences, The University of Melbourne, Melbourne, 3051 VIC, Australia;1. Université de Caen Basse-Normandie, F-14032 Caen, France;2. UMR 7208 BOREA CNRS INEE, F-14032 Caen, France;3. Plateforme Post-génomique PROTEOGEN, F-14032 Caen, France;4. Plateforme ABiMS, Station biologique de Roscoff (UPMC-CNRS), F-29688 Roscoff, France;1. Laboratory of Equine Exercise Physiology and Pharmacology, Department of Animal Morphology and Physiology, Faculdade de Ciências Agrárias e Veterinárias, UNESP—Univ Estadual Paulista, Jaboticabal, São Paulo, Brazil;2. Department of Animal Breeding and Nutrition, Faculdade de Medicina Veterinária e Zootecnia, UNESP—Univ Estadual Paulista, Botucatu, São Paulo, Brazil;3. Hospital Veterinário, Faculdade de Agronomia e Medicina Veterinária, Campus Universitário Darcy Ribeiro, Asa Norte, UnB—Universidade de Brasília, Brasília, Distrito Federal, Brazil;1. Division of Allergy, Immunology & Rheumatology, Department of Internal Medicine, Taichung Veterans General Hospital, Taichung, Taiwan;2. College of Life Sciences, National Chung Hsing University, Taichung, Taiwan;3. Institute of Clinical Medicine, National Yang Ming University, Taipei, Taiwan;4. Department of Medical Research, Taichung Veterans General Hospital, Taichung, Taiwan;5. Department of Medicine, Mackay Medical College, New Taipei, Taiwan;1. Key Laboratory of Experimental Marine Biology, Institute of Oceanology, Chinese Academy of Sciences, 7 Nanhai Road, Qingdao 266071, China;2. University of Chinese Academy of Sciences, Beijing 100049, China |
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| Abstract: | Basigin (BSG), also known as extracellular matrix metalloproteinase inducer (EMMPRIN) or cluster of differentiation 147 (CD147), plays various fundamental roles in the intercellular recognition involved in immunologic phenomena, differentiation, and development. In this study, we aimed to compare the similarities and differences of BSG among organisms and explore possible evolutionary relationships based on the comparison result. We used the extensive BLAST tool to search the metazoan genomes, N-glycosylation sites, the transmembrane region and other functional sites. We then identified BSG homologs from genomic sequences and analyzed their phylogenetic relationships. We identified that BSG genes exist not only in the vertebrate metazoans but also in the invertebrate metazoans such as Amphioxus B. floridae, D. melanogaster, A. mellifera, S. japonicum, C. gigas, and T. patagoniensis. After sequence analysis, we confirmed that only vertebrate metazoans and Cephalochordate (amphioxus B. floridae) have the classic structure (a signal peptide, two Ig-like domains (IgC2 and IgI), a transmembrane region, and an intracellular domain). The invertebrate metazoans (excluding amphioxus B. floridae) lack the N-terminal signal peptides and IgC2 domain. We then generated a phylogenetic tree, genome organization comparison, and chromosomal disposition analysis based on the biological information obtained from the NCBI and Ensembl databases. Finally, we established the possible evolutionary scenario of the BSG gene, which showed the restricted exon rearrangement that has occurred during evolution, forming the present-day BSG gene. |
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| Keywords: | Basigin (BSG) Evolution Comparative genomics Ig superfamily |
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