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Maternal choline supplementation during murine pregnancy modulates placental markers of inflammation,apoptosis and vascularization in a fetal sex-dependent manner
Institution:1. Division of Nutritional Sciences, Cornell University, Ithaca, NY, United States;2. Department of Biomedical Sciences, Cornell University, Ithaca, NY, United States;1. Department of Woman & Child, University Hospital Leuven, Katholieke Universiteit Leuven, B-3000 Leuven, Belgium;2. Department of Cardiovascular and Renal Research, Institute of Molecular Medicine, University of Southern Denmark, Odense, Denmark;1. Department of Obstetrics and Gynaecology, Spaarne Gasthuis, Spaarnepoort 1, 2134 TM, Hoofddorp, The Netherlands;2. Department of Clinical Pathology, Spaarne Gasthuis, Spaarnepoort 1, 2134 TM, Hoofddorp, The Netherlands;3. Department of Obstetrics and Gynaecology, Division of Obstetrics and Prenatal Medicine, Erasmus MC: University Medical Centre Rotterdam, ''s-Gravendijkwal 230, 3015 CE, The Netherlands;1. Fetal Therapy Unit “ U.Nicolini”, Vittore Buzzi Children''s Hospital, Università degli Studi di Milano, Milan, Italy;2. Epidemiology Unit, Fondazione IRCCS Ca’ Granda - Ospedale Maggiore Policlinico, Milan, Italy;1. Obstetrics, Nutrition and Endocrinology Group, Department of Obstetrics and Gynaecology, University of Melbourne, Victoria, Australia;2. Mercy Perinatal Research Centre, Mercy Hospital for Women, Victoria, Australia;1. Faculty of Pharmacy, Keio University, 1-5-30 Shibakoen, Minato-ku, Tokyo 105-8512, Japan;2. Department of Pharmaceutics, Graduate School of Medicine and Pharmaceutical Sciences, University of Toyama, 2630 Sugitani, Toyama 930-0194, Japan;3. Faculty of Pharmaceutical Sciences, Institute of Medical, Pharmaceutical and Health Sciences, Kanazawa University, Kakuma-machi, Kanazawa 920-1192, Japan;4. Division of Membrane Transport and Drug Targeting, Graduate School of Pharmaceutical Sciences, Tohoku University, 6-3 Aoba Aramaki, Aoba-ku, Sendai, Miyagi 980-8578, Japan;1. Division of Obstetrics and Gynecology, Nanfang Hospital, Southern Medical University, Guangzhou 510515, Guangdong, China;2. First School of Clinical Medicine, Southern Medical University, Guangzhou 510515, Guangdong, China;3. Division of Neurology, Nanfang Hospital, Southern Medical University, Guangzhou 510515, Guangdong, China
Abstract:
Keywords:Choline  Placenta  Inflammation  Angiogenesis  Fetal sex  Vegfa"}  {"#name":"keyword"  "$":{"id":"kwrd0040"}  "$$":[{"#name":"text"  "_":"vascular endothelial growth factor  Pgf"}  {"#name":"keyword"  "$":{"id":"kwrd0050"}  "$$":[{"#name":"text"  "_":"placental growth factor  sFLT1"}  {"#name":"keyword"  "$":{"id":"kwrd0060"}  "$$":[{"#name":"text"  "_":"soluble fms-like tyrosine kinase-1  sENG"}  {"#name":"keyword"  "$":{"id":"kwrd0070"}  "$$":[{"#name":"text"  "_":"soluble endoglin  Tnf"}  {"#name":"keyword"  "$":{"id":"kwrd0080"}  "$$":[{"#name":"text"  "_":"tumor necrosis factor alpha  Il6"}  {"#name":"keyword"  "$":{"id":"kwrd0090"}  "$$":[{"#name":"text"  "_":"interleukin 6  Il1b"}  {"#name":"keyword"  "$":{"id":"kwrd0100"}  "$$":[{"#name":"text"  "_":"interleukin 1 beta  Il10"}  {"#name":"keyword"  "$":{"id":"kwrd0110"}  "$$":[{"#name":"text"  "_":"interleukin 10  MCS"}  {"#name":"keyword"  "$":{"id":"kwrd0120"}  "$$":[{"#name":"text"  "_":"maternal choline supplementation  NSA"}  {"#name":"keyword"  "$":{"id":"kwrd0130"}  "$$":[{"#name":"text"  "_":"non-Swiss Albino  DMG"}  {"#name":"keyword"  "$":{"id":"kwrd0140"}  "$$":[{"#name":"text"  "_":"dimethylglycine  TMAO"}  {"#name":"keyword"  "$":{"id":"kwrd0150"}  "$$":[{"#name":"text"  "$$":[{"#name":"__text__"  "_":"trimethylamine "}  {"#name":"italic"  "_":"N"}  {"#name":"__text__"  "_":"-oxide  Nfkb1"}  {"#name":"keyword"  "$":{"id":"kwrd0160"}  "$$":[{"#name":"text"  "_":"nuclear factor of kappa light polypeptide gene enhancer in B-cells  Eng"}  {"#name":"keyword"  "$":{"id":"kwrd0170"}  "$$":[{"#name":"text"  "_":"endoglin  Mmp14"}  {"#name":"keyword"  "$":{"id":"kwrd0180"}  "$$":[{"#name":"text"  "_":"matrix metalloproteinase 14  Tbp"}  {"#name":"keyword"  "$":{"id":"kwrd0190"}  "$$":[{"#name":"text"  "_":"TATA box binding protein  TUNEL"}  {"#name":"keyword"  "$":{"id":"kwrd0200"}  "$$":[{"#name":"text"  "_":"terminal deoxynucleotidyl transferase dUTP nick end labeling  SMA"}  {"#name":"keyword"  "$":{"id":"kwrd0210"}  "$$":[{"#name":"text"  "_":"smooth muscle actin
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