尿白蛋白排泄率与2型糖尿病微血管病变的相关性分析

研究尿白蛋白排泄率(UAER)与糖尿病肾脏病变(DN)、视网膜病变(DR)之间的关系,并探讨与其有关的相关危险因素. 对465例2型糖尿病患者按UAER分成正常白蛋白尿组(NAU组,UAER＜20μg/min)、微量白蛋白尿组(MAU组,20μg/min ≤UAER＜200μg/min )和临床白蛋白尿组(CAU组,U...

Relationship Between Urinary Albumin Excretion Rate and Type-2 Diabetes Micro-angiopathy

To investigate the relationship among urinary albumin excretion rate（UAER）,type-2 diabetic nephropathy（DN）,and diabetic retinopathy（DR） and to explore the prevalence and risk factors of UAER.465 type-2 diabetic patients were divided into 3 groups： normal albuminuria group（NAU,UAER20μg/min）,microalbuminuria group（MAU,20μg/min ≤UAER200μg/min）,and clinical albuminuria group（CAU,UAER≥200μg/min）.Comparisons between possible factors were made among the 3 groups,and correlation analysis and stepwise regression analysis was applied to analyze UAER and these factors.The risk factors of microangiopathy were determined by logistic analysis.The results showed that the prevalence of DN was 33.55%,including 22.37% of MAU,and 11.18% of CAU.The prevalence of DR was 38.13%,including 26.91% of BDR,and 11.22% of PDR.There were statistically significant differences in terms of SBP,DBP,FBG,BUN,TG,HDL-C,and prevalence of DR among the three groups（P0.05）.The TC and Cr were independent positively correlated with UAER（P0.05）.The logistic regression analysis showed that UAER,diabetic duration,TC,CP2 and DN were the independent risk factors of DR（P0.05）.SBP、TC、Cr and DR were the independent risk factors of DN（P0.05）.UAER was closely associated with TC and Cr.DN and DR were the independent risk factor of each other,and demonstrated a close relationship.