The effect of seizure severity on quality of life in epilepsy |
| |
Authors: | Harden Cynthia L Maroof David Aaron Nikolov Blagovest Fowler Kristen Sperling Michael Liporace Joyce Pennell Page Labar Douglas Herzog Andrew |
| |
Affiliation: | Comprehensive Epilepsy Center, New York Presbyterian Hospital, Weill Medical College of Cornell University, New York, NY 10021, USA. clharden@mail.med.cornell.edu |
| |
Abstract: | Seizure severity is an important aspect of epilepsy. The relationship between seizure severity and quality of life in epilepsy, however, has been incompletely explored. With a data set of 118 women from the baseline phase of a clinical treatment trial, the relationship between seizure severity and aspects of quality of life was evaluated. Two domains of the Quality of Life in Epilepsy-31 (QOLIE-31) correlated highly significantly with seizure severity: Seizure Worry (r=-0.265, P=.004) and Social Functioning (r=-0.280, P=0.002). Two additional domains were significantly correlated: Overall Quality of Life (r=-0.210, P=0.023) and Cognitive (r=-0.209, P=0.024). When the potentially confounding effect of depression, measured by the Beck Depression Inventory, was controlled for, the regression of seizure severity with QOLIE-31 Seizure Worry remained significant (P=0.006, R(2)=0.153), as did the regression with QOLIE-31 Social Functioning (P=0.002, R(2)=0.184) and the regression with QOLIE-31 Cognitive (P=0.037, R(2)=0.30). These findings indicate that severe and potentially injurious seizure behaviors contribute to anxiety and socially avoidant behavior for persons with intractable epilepsy. |
| |
Keywords: | |
本文献已被 PubMed 等数据库收录! |
|