Parathyroid Hormone and T-Cellular Immunity in Uremic Patients in Replacement Dialytic Therapy |
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| Authors: | Daniela Angelini,Antonio Carlini,Riccardo Giusti,Riccardo Grassi,Ermenegildo Mei,Italbo Fiorini&dagger ,Luisa Mazzotta,Alessandro Antonelli |
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| Affiliation: | Department of Nephrology, Hospital of Lucca, Lucca, Italy;*Department of Analysis, Hospital of Lucca, Lucca, Italy;†Department of Endocrinology, Hospital of Lucca, Lucca, Italy |
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| Abstract: | Abstract: We studied 54 patients in replacement dialytic therapy divided into two groups: Group 1, 26 patients with normal parathyroid hormone (PTH) (10–80 pg/ml); and Group 2, 28 patients with elevated PTH (80–400 pg/ml). Total T lymphocytes, CD4, CD8, and CD4/CD8 ratio were evaluated. We found a reduction of total T lymphocytes in both groups compared with controls. A decrease of CD4 and CD4/CD8 ratio with a rise of CD8 occurred in Group 2 but not in Group 1. In Group 2, PTH presented a linear correlation with CD8 and a reverse correlation with total T cells, CD4, and CD4/CD8 ratio. PTH might act on T-cellular immunity with an immunosuppressive effect from the earlier phases of hyperparathyroidism. |
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| Keywords: | Parathyroid hormone T-cellular immunity Hemodialysis |
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