| 激素抵抗性前列腺癌化疗15例报告 |
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| 引用本文： | 喻彬,须霆,邹青,杨尔炘,汪仪俊. 激素抵抗性前列腺癌化疗15例报告[J]. 现代肿瘤医学, 2010, 18(4). DOI: 10.3969/j.issn.1672-4992.2010.04.41 |
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| 作者姓名： | 喻彬 须霆 邹青 杨尔炘 汪仪俊 |
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| 作者单位： | 江苏省肿瘤医院(江苏省肿瘤防治研究所)泌尿外科,江苏,南京,210009 |
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| 摘 要： | 目的:探讨多西紫杉醇联合泼尼松治疗内分泌治疗失败前列腺癌的应用价值.方法:入选15例非激素依赖性前列腺癌患者,给予多西紫杉醇75 mg /m2,第1天;泼尼松5 mg bid,第1 -21 天,21天为1 个周期,每例接受化疗6-10个周期不等.结果:本组病例随访6 -87 周,中位61周.其中26.7% (4 /15)完全缓解,46.7% (7 /15 ) 部分缓解,20.0% ( 3 /15 ) 稳定,6.66% (1 /15)进展.缓解和稳定患者的PSA进展中位时间是40.3周(13-67周).8例骨痛患者中5例疼痛缓解.中位生存期大于12个月.不良反应可耐受.结论:多西紫杉醇联合泼尼松治疗激素抵抗性前列腺癌有较好疗效,不良反应轻.
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| 关 键 词： | 前列腺癌 激素抵抗 化疗 多西紫杉醇 |
Clinical results of chemotherapy for hormone refractory prostate cancer:A report of 15 cases |
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| YU Bin,XU Ting,ZOU Qing,YANG Er-xin,WANG Yi-jun. Clinical results of chemotherapy for hormone refractory prostate cancer:A report of 15 cases[J]. Journal of Modern Oncology, 2010, 18(4). DOI: 10.3969/j.issn.1672-4992.2010.04.41 |
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| Authors: | YU Bin XU Ting ZOU Qing YANG Er-xin WANG Yi-jun |
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| Affiliation: | YU Bin,XU Ting,ZOU Qing,YANG Er-xin,WANG Yi-jun Department of Urology,Jiangsu Cancer Hospital,Nanjing 210009,China. |
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| Abstract: | Objective:To evaluate the efficacy of docetaxel plus prednisone in treating hormone refractory prostate cancer and to evaluate it's adverse events.Methods:Fifteen patients with metastatic hormone refractory prostate cancer were candidated and given a combination of docetaxel 75mg/ m2 intravenously on day 1 and prednisone 5 mg twice daily on day 1-21,21 days a cycle.Each patient accepted a chemotherapy of 6-8 cycles.Results:The patients were followed-up for 6-87 weeks(mean time 61 weeks),26.7%(4 /15) of them... |
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| Keywords: | prostate cancer hormone refractory chemotherapy docetaxel |
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