| 序列接近性配型方法预测异基因造血干细胞移植后GVHD的发生 |
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| 引用本文： | 赵丹丹,刘周阳,曹永彬,蒋双,达万明,吴晓雄.序列接近性配型方法预测异基因造血干细胞移植后GVHD的发生[J].中国实验血液学杂志,2010,18(3):740-743. |
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| 作者姓名： | 赵丹丹 刘周阳 曹永彬 蒋双 达万明 吴晓雄 |
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| 作者单位： | 解放军总医院第304临床部血液科,北京,100048 |
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| 摘 要： | 本研究探讨序列接近性配型（sequence similar matching，SSM）方法对HLA不相合异基因造血干细胞移植后GVHD的预测作用；利用2005—2009年我科进行的23例HLA不相合移植资料，通过SSM软件进行分析比较和数值计算。结果表明：总分值小于55分的异基因造血干细胞移植患者的急性GVHD和重度GVHD的发生率小。结论：SSM软件在HLA不相合造血干细胞移植中对GVHD有一定的预测作用。
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| 关 键 词： | SSM HLA 异基因造血干细胞移植 |
Prediction of the GVHD after Allo-HSCT by Sequence Similar Matching Method |
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| ZHAO Dan-Dan,LIU Zhou- Yang,CAO Yong-Bin,JIANG Shuang,DA Wan-Ming,WU Xiao-Xiong.Prediction of the GVHD after Allo-HSCT by Sequence Similar Matching Method[J].Journal of Experimental Hematology,2010,18(3):740-743. |
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| Authors: | ZHAO Dan-Dan LIU Zhou- Yang CAO Yong-Bin JIANG Shuang DA Wan-Ming WU Xiao-Xiong |
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| Institution: | ( Department of Hematology, 304th Clinical Division, Chinese PLA General Hospital, Beijing, 100048 China ) |
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| Abstract: | This study was aimed to investigate the role of sequence similar matching （SSM） method in prediction of GVHD after HLA unmatched allogeneic hematopoietic stem cell transplantation （allo-HSCT）. The data from 23 patients undergoing HLA unmatched allo-HSCT were analyzed and calculated by SSM method. The results showed that the incidence of acute and severe GVHD were significantly less in the allo-HSCT cases with total SSM value less than 55. In conclusion, the SSM method can be used to predict GVHD in the HLA-unmatched allogeneic hematopoietic stem cell transplantation. |
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| Keywords: | SSM HLA |
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